4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Product Name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- CAS No.
- 1197377-47-1
- Chemical Name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Synonyms
- (3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile;4-(3-AMINO-1,2,4-TRIAZIN-6-YL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(3-amino-1,2,4-triazin-6-yl)-2-fluoro-
- CBNumber
- CB12652323
- Molecular Formula
- C10H6FN5
- Formula Weight
- 215.19
- MOL File
- 1197377-47-1.mol
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Property
- Boiling point:
- 497.4±55.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3 (20 ºC 760 Torr)
- pka
- 2?+-.0.63(Predicted)
- InChI
- InChI=1S/C10H6FN5/c11-8-3-6(1-2-7(8)4-12)9-5-14-10(13)16-15-9/h1-3,5H,(H2,13,14,16)
- InChIKey
- JXQHTMHBDHVPDQ-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C2N=NC(N)=NC=2)C=C1F
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0101071
- Product name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Purity
- 97.05%
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0101071
- Product name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Purity
- 97.05%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 2209AQ
- Product name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Packaging
- 250mg
- Price
- $244.4
- Updated
- 2021/12/16
- Product number
- CS-0101071
- Product name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Purity
- 97.05%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0101071
- Product name
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Purity
- 97.05%
- Packaging
- 5g
- Price
- $750
- Updated
- 2021/12/16
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Chemical Properties,Usage,Production
Uses
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is a useful research chemical compound used in the preparation of salts of [(quinolinylmethyl)imidazotriazinyl]benzamide as tyrosine kinase inhibitors useful in the treatment of diseases.
Synthesis
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile could be synthesize from the reaction of 6-bromo-1,2,4-triazin-3-amine with 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile. A solution concluding these two compounds in 1,4-dioxane (1200 mL) was stirred before K2CO3 was added. The reaction mixture was degassed by bubbling with nitrogen before 1,1'-bis(diphenyl phosphine)ferrocene dichloropalladium(II) complex with dichloromethane (1:1) (Pd(dppf)2Cl2 was added. The resulting reaction mixture was degassed by bubbling with nitrogen and then heated at 86° C. After the reaction mixture was cooled to 0-5° C. 1,4-Dioxane was added before aqueous hydrochloric acid solution was added dropwise to adjust pH to 0.40-0.93. The mixture was stirred at for 30 min and filtered. The solid collected was stirred with 1,4-dioxane, and HCl added. Finally, after purification, product 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile was obtained.
Solubility in organics
Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.
storage
Keep in dark place,Inert atmosphere,Room temperature
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile manufacturers
- Product
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98% by HPLC
- Supply Ability
- 100kg/month
- Release date
- 2023-07-22
- Product
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-21
- Product
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28