Birinapant

Product Name: Birinapant
CAS No.: 1260251-31-7
Chemical Name: Birinapant
Synonyms: CS-801;TL 32711;Birinapan;Birinapant;SMAC mimetic;TL-32711 ≥98%;Birinapant, >=98%;Birinapant (TL32711);TL 32711. Birinapant;Birinapant USP/EP/BP
CBNumber: CB12658183
Molecular Formula: C42H56F2N8O6
Formula Weight: 806.94
MOL File: 1260251-31-7.mol

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Birinapant Property

Melting point:: >245oC (dec.)
Boiling point:: 1090.5±65.0 °C(Predicted)
Density: 1.320±0.06(20.0000℃)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 13.99±0.46(Predicted)
form: Solid
color: White to Off-White

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19699
Product name: Birinapant
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19699
Product name: Birinapant
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 19699
Product name: Birinapant
Purity: ≥95%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 19699
Product name: Birinapant
Purity: ≥95%
Packaging: 25mg
Price: $616
Updated: 2024/03/01

TRC

Product number: B399730
Product name: Birinapant
Packaging: 5mg
Price: $140
Updated: 2021/12/16

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Birinapant Chemical Properties,Usage,Production

Description

Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.

Uses

Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.

Definition

ChEBI: Birinapant is a dipeptide.

Enzyme inhibitor

This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors

target

XIAP

Birinapant Preparation Products And Raw materials

Raw materials

Preparation Products

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Birinapant Suppliers

China 114 India 2 United States 21 Global 137

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

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View Lastest Price from Birinapant manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Birinapant 1260251-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

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Birinapant

Birinapant (TL32711)

TL 32711

Birinapant(TL32711)/TL-32711/TL32711/TL-32711

(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide

Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)-

(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant TL 32711

Birinapant (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide

Birinapant, >=98%

(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]b

Birinapant, Free Base

Birinapan

TL-32711 ≥98%

(2S,2'S)-N,N'-[(6,6'-DIFLUORO[2,2'-BI-1H-INDOLE]-3,3'-DIYL)BIS[METHYLENE[(2R,4S)-4-HYDROXY-2,1-PYRRO

TL 32711. Birinapant

TL-32711; TL32711; TL 32711. BIRINAPANT

CS-801

Birinapant USP/EP/BP

(2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-Difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide)

SMAC mimetic

(2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-Difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide)

1260251-31-7

C42H56F2N8O6

Inhibitors

Inhibitor