Methyl 6-chloro-5-(trifluoroMethyl)picolinate

Product Name: Methyl 6-chloro-5-(trifluoroMethyl)picolinate
CAS No.: 1211518-35-2
Chemical Name: Methyl 6-chloro-5-(trifluoroMethyl)picolinate
Synonyms: Methyl 6-chloro-5-(trifluoroMethyl)picolinate;Methyl 6-chloro-5-(trifluoromethyl)pyridine-2-carboxylate;6-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-chloro-5-(trifluoromethyl)-, methyl ester
CBNumber: CB12661167
Molecular Formula: C8H5ClF3NO2
Formula Weight: 239.58
MOL File: 1211518-35-2.mol

More

Less

Methyl 6-chloro-5-(trifluoroMethyl)picolinate Property

Boiling point:: 299.8±40.0 °C(Predicted)
Density: 1.443±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.45±0.10(Predicted)
Appearance: Off-white to light yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0041631
Product name: Methyl6-chloro-5-(trifluoromethyl)picolinate
Purity: 98.69%
Packaging: 1g
Price: $183
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369605
Product name: METHYL-6-CHLORO-5-(TRIFLUOROMETHYL)PICOLINATE
Purity: 95.00%
Packaging: 5MG
Price: $504.61
Updated: 2021/12/16

ChemScene

Product number: CS-0041631
Product name: Methyl6-chloro-5-(trifluoromethyl)picolinate
Purity: 98.69%
Packaging: 5g
Price: $638
Updated: 2021/12/16

AK Scientific

Product number: Z3982
Product name: Methyl6-chloro-5-(trifluoromethyl)picolinate
Packaging: 5g
Price: $919
Updated: 2021/12/16

AK Scientific

Product number: Z3982
Product name: Methyl6-chloro-5-(trifluoromethyl)picolinate
Packaging: 100mg
Price: $99
Updated: 2021/12/16

More

Less

Methyl 6-chloro-5-(trifluoroMethyl)picolinate Chemical Properties,Usage,Production

Uses

Methyl 6-Chloro-5-(trifluoromethyl)picolinate is used in preparation of pyridine amides as cannabinoid CB2 receptor agonists.

Synthesis

1415899-18-1

1211518-35-2

Methyl oxo-5-trifluoromethylpyridine-2-carboxylate (2.2 g, 10 mmol) was added batchwise to phosphoric acid trichloride (CAS 10025-87-3, 10 mL) at 0 °C, the reaction mixture was stirred and reacted at 50 °C overnight. Upon completion of the reaction, the solvent was removed by vacuum distillation to give a brown oil. The oily substance was dissolved in ethyl acetate (30 mL) and minimally neutralized with aqueous sodium carbonate. The neutralized mixture was extracted with ethyl acetate (2 x 30 mL), the organic phases were combined and washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give a light brown solid. Purification of the above solid by column chromatography (silica gel, 15 g, 3% petroleum ether solution of ethyl acetate) resulted in methyl 6-chloro-5-(trifluoromethyl)pyridinecarboxylate (1.5 g, 63% yield) as a white solid; mass spectrum (EI): m/e = 240.0 [M + H]+.

References

[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 77
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 159; 160
[3] Patent: WO2014/86705, 2014, A1. Location in patent: Page/Page column 62

Methyl 6-chloro-5-(trifluoroMethyl)picolinate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 6-chloro-5-(trifluoroMethyl)picolinate Suppliers

China 56 India 2 United States 4 Global 62

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Shanghai Chenzhu Pharmaceutical Co., Ltd.

Tel: 13162380607
Fax: QQ:1696175688
Email: 1696175688@qq.com
Country: China
ProdList: 817
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 0512-0512-52358471 17715136450
Fax: 05125235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 12127
Advantage: 58

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4985
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

1211518-35-2, Methyl 6-chloro-5-(trifluoroMethyl)picolinateRelated Search:

METHYL 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINATE methyl 6-fluoro-5-(trifluoromethyl)nicotinate

6-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Methyl 6-chloro-5-(trifluoroMethyl)picolinate

2-Pyridinecarboxylic acid, 6-chloro-5-(trifluoromethyl)-, methyl ester

Methyl 6-chloro-5-(trifluoromethyl)pyridine-2-carboxylate

1211518-35-2