ChemicalBook > CAS DataBase List > (S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

Product Name
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
CAS No.
99208-71-6
Chemical Name
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
Synonyms
EOS-61025;(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane;(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one;(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one;(7aS)-3,3-dimethyl-hexahydropyrrolo[1,2-c][1,3]oxazol-5-one;(S)-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one;3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (7aS)-;(7aS)-3,3-dimethyl-1,6,7,7a-tetrahydropyrrolo[1,2-c][1,3]oxazol-5-one;1-(3,4-Dimethoxyphenethyl)-4-(7-phenylpropyl piperazinedihydrochloride
CBNumber
CB12662250
Molecular Formula
C8H13NO2
Formula Weight
155.19
MOL File
99208-71-6.mol
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(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Property

Boiling point:
262.2±19.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-0.70±0.40(Predicted)
Appearance
white solid
CAS DataBase Reference
99208-71-6
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

AK Scientific
Product number
4166BB
Product name
(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
Packaging
250mg
Price
$161
Updated
2021/12/16
Activate Scientific
Product number
AS46967
Product name
(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
Purity
97+% ee
Packaging
1g
Price
$289
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0033294
Product name
(S)-3,3-DIMETHYLTETRAHYDROPYRROLO[1,2-C]OXAZOL-5(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$500.18
Updated
2021/12/16
Activate Scientific
Product number
AS46967
Product name
(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
Purity
97+% ee
Packaging
5G
Price
$832
Updated
2021/12/16
Chemenu
Product number
CM126669
Product name
(S)-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
Purity
95%
Packaging
10g
Price
$916
Updated
2021/12/16
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(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Chemical Properties,Usage,Production

Synthesis

77-76-9

17342-08-4

99208-71-6

To a 500 ml solution of toluene containing 23.12 g of (S)-(+)-5-hydroxymethyl-2-pyrrolidinone and 0.18 g of p-toluenesulfonic acid, 70 ml of 2,2-dimethoxypropane was slowly added at room temperature. The reaction mixture was heated to reflux with continuous stirring for 2 hours. Subsequently, the volatile components were removed by distillation at a temperature range of 65°C to 92°C. To the residue, 70 ml of 2,2-dimethoxypropane was added again and the mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was cooled and concentrated to afford the crude product (S)-3,3-dimethyltetrahydropyrrolo[1,2-c]oxazol-5-(3H)-one. The final yield was 29.82 g in 96% of the theoretical value.

References

[1] Patent: US2013/23502, 2013, A1. Location in patent: Paragraph 0322-0324
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 6, p. 647 - 658
[3] Journal of Organic Chemistry, 2001, vol. 66, # 26, p. 8831 - 8842
[4] Organic letters, 1999, vol. 1, # 13, p. 2105 - 2107
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 23, p. 6885 - 6893

(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Suppliers

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99208-71-6, (S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-oneRelated Search:

Poly(dimethylsiloxane) Dimethyl sulfone

  • (S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
  • (S)-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
  • (7aS)-3,3-dimethyl-hexahydropyrrolo[1,2-c][1,3]oxazol-5-one
  • EOS-61025
  • (S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one
  • (7aS)-3,3-dimethyl-1,6,7,7a-tetrahydropyrrolo[1,2-c][1,3]oxazol-5-one
  • (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane
  • 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (7aS)-
  • 1-(3,4-Dimethoxyphenethyl)-4-(7-phenylpropyl piperazinedihydrochloride
  • 99208-71-6