(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- Product Name
- (S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- CAS No.
- 99208-71-6
- Chemical Name
- (S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- Synonyms
- EOS-61025;(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane;(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one;(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one;(7aS)-3,3-dimethyl-hexahydropyrrolo[1,2-c][1,3]oxazol-5-one;(S)-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one;3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (7aS)-;(7aS)-3,3-dimethyl-1,6,7,7a-tetrahydropyrrolo[1,2-c][1,3]oxazol-5-one;1-(3,4-Dimethoxyphenethyl)-4-(7-phenylpropyl piperazinedihydrochloride
- CBNumber
- CB12662250
- Molecular Formula
- C8H13NO2
- Formula Weight
- 155.19
- MOL File
- 99208-71-6.mol
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Property
- Boiling point:
- 262.2±19.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -0.70±0.40(Predicted)
- Appearance
- white solid
- CAS DataBase Reference
- 99208-71-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 4166BB
- Product name
- (S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- Packaging
- 250mg
- Price
- $161
- Updated
- 2021/12/16
- Product number
- AS46967
- Product name
- (S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- CCH0033294
- Product name
- (S)-3,3-DIMETHYLTETRAHYDROPYRROLO[1,2-C]OXAZOL-5(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.18
- Updated
- 2021/12/16
- Product number
- AS46967
- Product name
- (S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
- Purity
- 97+% ee
- Packaging
- 5G
- Price
- $832
- Updated
- 2021/12/16
- Product number
- CM126669
- Product name
- (S)-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
- Purity
- 95%
- Packaging
- 10g
- Price
- $916
- Updated
- 2021/12/16
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Chemical Properties,Usage,Production
Synthesis
77-76-9
17342-08-4
99208-71-6
To a 500 ml solution of toluene containing 23.12 g of (S)-(+)-5-hydroxymethyl-2-pyrrolidinone and 0.18 g of p-toluenesulfonic acid, 70 ml of 2,2-dimethoxypropane was slowly added at room temperature. The reaction mixture was heated to reflux with continuous stirring for 2 hours. Subsequently, the volatile components were removed by distillation at a temperature range of 65°C to 92°C. To the residue, 70 ml of 2,2-dimethoxypropane was added again and the mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was cooled and concentrated to afford the crude product (S)-3,3-dimethyltetrahydropyrrolo[1,2-c]oxazol-5-(3H)-one. The final yield was 29.82 g in 96% of the theoretical value.
References
[1] Patent: US2013/23502, 2013, A1. Location in patent: Paragraph 0322-0324
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 6, p. 647 - 658
[3] Journal of Organic Chemistry, 2001, vol. 66, # 26, p. 8831 - 8842
[4] Organic letters, 1999, vol. 1, # 13, p. 2105 - 2107
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 23, p. 6885 - 6893
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one Suppliers
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