ChemicalBook > CAS DataBase List > 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

Product Name
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
CAS No.
852391-15-2
Chemical Name
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
Synonyms
Nec-1s;CS-2815;7-Cl-O-Nec1;Nec-1s(7-Cl-O-Nec1);Necrostatin-2 raceMate;Necrostatin 2 (raceMate);Necrostatin 2 racemate (Nec-1s);RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem;5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione);5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
CBNumber
CB12662775
Molecular Formula
C13H12ClN3O2
Formula Weight
277.71
MOL File
852391-15-2.mol
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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Property

Melting point:
173-175℃
Density 
1.450±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
Off-white to pale yellow solid
pka
8.48±0.70(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.04297
Product name
RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
Packaging
10mg
Price
$258
Updated
2023/01/07
Cayman Chemical
Product number
20924
Product name
(±)-Necrostatin-2
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
20924
Product name
(±)-Necrostatin-2
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
20924
Product name
(±)-Necrostatin-2
Purity
≥98%
Packaging
10mg
Price
$216
Updated
2024/03/01
AK Scientific
Product number
8960CC
Product name
Necrostatin2racemate
Packaging
5mg
Price
$221
Updated
2021/12/16
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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Chemical Properties,Usage,Production

Description

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5

Uses

Necrostatin 1s is an inhibitor of indolamine 2,3-deoxygenase. Necrostatin 1s is a neuroprotective with potential therapeutic functions against brain ischemia.

References

1) Degterev?et al. (2005)?Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?1?112 2) Teng?et al. (2005)?Structure-activity relationship of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett.,?15?5039 3) Degterev?et al. (2012)?Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase; Cell Death Differ.,?20?366 4) Takahashi?et al. (2012)?Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models; Cell Death Dis.,?3?e437 5) Degterev?et al. (2013)?Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?9?192

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Preparation Products And Raw materials

Raw materials

Preparation Products

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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Suppliers

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852391-15-2, 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)Related Search:

TYRPHOSTIN AG 1296 GW441756 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

  • 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
  • 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
  • Necrostatin 2 (raceMate)
  • Necrostatin-2 raceMate
  • 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-
  • 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
  • Nec-1s(7-Cl-O-Nec1)
  • RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
  • Nec-1s
  • CS-2815
  • 7-Cl-O-Nec1
  • Nec-1S,Nec-1,Necrostatin 1S,inhibit,necroptosis,necrostatin,Necrostatin 2,Receptor-interacting protein kinases,Necrostatin-2,Necrostatin2,Necrostatin 2 racemate,IDO,Inhibitor,stable,RIPK1,RIP kinase,RIPK
  • Necrostatin 2 racemate (Nec-1s)
  • 852391-15-2