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2-Chloro-4-fluoro-5-nitrophenol

Product Name
2-Chloro-4-fluoro-5-nitrophenol
CAS No.
84478-75-1
Chemical Name
2-Chloro-4-fluoro-5-nitrophenol
Synonyms
2-Chloro-4-fluoro-5-nitropheno;2-CHLORO-4-FLUORO-5-NITROPHENOL;2-CHLORO-4-FLUORO-5-NITROBENZENOL;Phenol, 2-chloro-4-fluoro-5-nitro-;2-Chloro-4-fluoro-5-nitrophenol >4-Chloro-2-fluoro-5-hydroxynitrobenzene;2-Chloro-4-fluoro-5-nitrophenol ISO 9001：2015 REACH
CBNumber
CB1266348
Molecular Formula
C6H3ClFNO3
Formula Weight
191.54
MOL File
84478-75-1.mol
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2-Chloro-4-fluoro-5-nitrophenol Property

Melting point:
105-108°C
Boiling point:
298.7±40.0 °C(Predicted)
Density 
1.653±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
6.58±0.24(Predicted)
color 
Light orange to Yellow to Green
InChI
InChI=1S/C6H3ClFNO3/c7-3-1-4(8)5(9(11)12)2-6(3)10/h1-2,10H
InChIKey
NAWVMCKMQMJQMF-UHFFFAOYSA-N
SMILES
C1(O)=CC([N+]([O-])=O)=C(F)C=C1Cl
CAS DataBase Reference
84478-75-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2908990000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00043
Product name
2-Chloro-4-fluoro-5-nitrophenol
Packaging
1g
Price
$167
Updated
2023/06/20
TCI Chemical
Product number
C2616
Product name
2-Chloro-4-fluoro-5-nitrophenol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$325
Updated
2025/07/31
TCI Chemical
Product number
C2616
Product name
2-Chloro-4-fluoro-5-nitrophenol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$1139
Updated
2025/07/31
TRC
Product number
C585080
Product name
2-Chloro-4-fluoro-5-nitrophenol
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C585080
Product name
2-Chloro-4-fluoro-5-nitrophenol
Packaging
250mg
Price
$55
Updated
2021/12/16
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2-Chloro-4-fluoro-5-nitrophenol Chemical Properties,Usage,Production

Synthesis

84478-89-7

84478-75-1

2-Chloro-4-fluoro-5-nitrophenyl methyl carbonate (120 g, 0.48 mol) was mixed with sodium hydroxide (22.7 g, 0.57 mol) in water (300 mL) and the reaction was carried out at reflux for 4 hrs. Upon completion of the reaction, the insoluble solids were removed by filtration and the filtrate was acidified with dilute hydrochloric acid to pH < 7. Subsequently, the precipitated solid product was collected by filtration, washed with water and dried to afford 2-chloro-4-fluoro-5-nitrophenol (90 g, 98% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.18 (s, 1H), 8.10 (d, J=10.4 Hz, 1H), 7.62 (d, J=7.2 Hz, 1H); mass spectrum (ESI) m/z: 192.1 ([M+H]+).

References

[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 38
[2] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 75
[3] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00252
[4] Organic Process Research and Development, 2014, vol. 18, # 1, p. 122 - 134
[5] Patent: US2008/234267, 2008, A1. Location in patent: Page/Page column 15

2-Chloro-4-fluoro-5-nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

FLUMICLORAC-PENTYL
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2-Chloro-4-fluoro-5-nitrophenol Suppliers

Americas 1 China 159 Europe 3 France 1 Germany 2 India 4 Italy 1 Japan 1 United Kingdom 15 United States 32 Global 219
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 2-Chloro-4-fluoro-5-nitrophenol manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-07

84478-75-1, 2-Chloro-4-fluoro-5-nitrophenolRelated Search:

2-Chloro-5-nitrophenol 2-Chloro-4-nitrophenol 2-Chloro-4-fluorophenol 4-Chlorophenol 2-Nitrophenol 3-Nitrophenol 4-Nitrophenol Difluorochloromethane Nitrophenol 2,5-DINITROPHENOL PICRIC ACID o-Anisaldehyde 4-Chloro-2-fluoronitrobenzene 3-AMINO-2,6-DIMETHYLPYRIDINE 4-Fluoro-3-nitrophenol 3-Amino-4-fluorophenol 1-CHLORO-5-FLUORO-2-(4-FLUOROBENZYLOXY)-4-NITROBENZENE ETHYL 2-(2-CHLORO-4-FLUORO-5-NITROPHENOXY)ACETATE

  • 2-Chloro-4-fluoro-5-nitropheno
  • 2-CHLORO-4-FLUORO-5-NITROBENZENOL
  • 2-CHLORO-4-FLUORO-5-NITROPHENOL
  • 4-Chloro-2-fluoro-5-hydroxynitrobenzene
  • 2-Chloro-4-fluoro-5-nitrophenol &gt
  • Phenol, 2-chloro-4-fluoro-5-nitro-
  • 2-Chloro-4-fluoro-5-nitrophenol ISO 9001：2015 REACH
  • 84478-75-1
  • C6H3ClFNO3
  • C6H3NO3ClF
  • Phenyls & Phenyl-Het
  • Phenol&Thiophenol&Mercaptan
  • API intermediates
  • Phenyls & Phenyl-Het