2-Chloro-5-nitrophenol
- Product Name
- 2-Chloro-5-nitrophenol
- CAS No.
- 619-10-3
- Chemical Name
- 2-Chloro-5-nitrophenol
- Synonyms
- NSC 212119;TIMTEC-BB SBB001524;2-Chloro-5-nitrophen;2-Chloro-5-Nirophenol;2-choro-5-nitrophenol;5-Nitro-2-Chlorophenol;2-CHLORO-5-NITROPHENOL;2-Chloro-5-nitrophenol>Phenol, 2-chloro-5-nitro-;4-Chloro-3-hydroxynitrobenzene
- CBNumber
- CB2695792
- Molecular Formula
- C6H4ClNO3
- Formula Weight
- 173.55
- MOL File
- 619-10-3.mol
2-Chloro-5-nitrophenol Property
- Melting point:
- 118-121°C
- Boiling point:
- 276.1±25.0 °C(Predicted)
- Density
- 1.554±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.72±0.19(Predicted)
- color
- Brown
- InChIKey
- BUMGQSCPTLELLS-UHFFFAOYSA-N
- CAS DataBase Reference
- 619-10-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Harmful/Irritant
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2077
- Product name
- 2-Chloro-5-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- C2077
- Product name
- 2-Chloro-5-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- C373925
- Product name
- 2-Chloro-5-nitrophenol
- Packaging
- 25g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- C373925
- Product name
- 2-Chloro-5-nitrophenol
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 072910
- Product name
- 2-Chloro-5-nitrophenol
- Purity
- 95+%
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
2-Chloro-5-nitrophenol Chemical Properties,Usage,Production
Chemical Properties
Light Brown Crystalline Solid
Uses
2-Chloro-5-nitrophenol (cas# 619-10-3) is a compound useful in organic synthesis.
Synthesis
121-88-0
619-10-3
General procedure for the synthesis of 2-chloro-5-nitrophenol from 2-amino-5-nitrophenol: In Preparation Example 14, 1-amino-5-nitrophenol (2 g, 12.97 mmol) and sodium nitrite (0.9 g, 12.97 mmol) were firstly dissolved in 10 ml of water and stirred well. Subsequently, 30 ml of 48% fluoboric acid (HBF4) was slowly added at room temperature with continuous stirring for 30 minutes. Next, copper (I) chloride (642 mg, 6.48 mmol) was added and the reaction mixture was heated to 80°C and maintained for 3 hours. After completion of the reaction, the mixture was poured into ice-cold water at 0°C and extracted with 200 ml of saturated sodium bicarbonate solution and 200 ml of ethyl acetate. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. Purification by column chromatography (hexane/ethyl acetate, 15/1) gave 2-chloro-5-nitrophenol (0.46 g, 23% yield). Referring to the exemplary method of synthesis 9, the target compound (0.167 g, 94% yield) was further reacted with 2-chloro-5-nitrophenol (0.36 g, 2.29 mmol).
References
[1] Patent: US2011/9390, 2011, A1. Location in patent: Page/Page column 16
[2] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 128-129
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 3, p. 668 - 671
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7398 - 7405
[5] Tetrahedron Letters, 2005, vol. 46, # 23, p. 4023 - 4026
2-Chloro-5-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-nitrophenol manufacturers
- Product
- 2-Chloro-5-nitrophenol 619-10-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-28
- Product
- 2-CHLORO-5-NITROPHENOL 619-10-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 20tons
- Release date
- 2024-09-20
- Product
- 2-Chloro-5-nitrophenol 619-10-3
- Price
- US $0.10-0.30/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2024-01-16