2-Chloro-4-fluoro-5-nitrophenol

Product Name: 2-Chloro-4-fluoro-5-nitrophenol
CAS No.: 84478-75-1
Chemical Name: 2-Chloro-4-fluoro-5-nitrophenol
Synonyms: 2-Chloro-4-fluoro-5-nitropheno;2-CHLORO-4-FLUORO-5-NITROPHENOL;2-CHLORO-4-FLUORO-5-NITROBENZENOL;Phenol, 2-chloro-4-fluoro-5-nitro-;2-Chloro-4-fluoro-5-nitrophenol >4-Chloro-2-fluoro-5-hydroxynitrobenzene;2-Chloro-4-fluoro-5-nitrophenol ISO 9001：2015 REACH
CBNumber: CB1266348
Molecular Formula: C6H3ClFNO3
Formula Weight: 191.54
MOL File: 84478-75-1.mol

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2-Chloro-4-fluoro-5-nitrophenol Property

Melting point:: 105-108°C
Boiling point:: 298.7±40.0 °C(Predicted)
Density: 1.653±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 6.58±0.24(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C6H3ClFNO3/c7-3-1-4(8)5(9(11)12)2-6(3)10/h1-2,10H
InChIKey: NAWVMCKMQMJQMF-UHFFFAOYSA-N
SMILES: C1(O)=CC([N+]([O-])=O)=C(F)C=C1Cl
CAS DataBase Reference: 84478-75-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2908990000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CVT00043
Product name: 2-Chloro-4-fluoro-5-nitrophenol
Packaging: 1g
Price: $167
Updated: 2023/06/20

TCI Chemical

Product number: C2616
Product name: 2-Chloro-4-fluoro-5-nitrophenol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $325
Updated: 2025/07/31

TCI Chemical

Product number: C2616
Product name: 2-Chloro-4-fluoro-5-nitrophenol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $1139
Updated: 2025/07/31

TRC

Product number: C585080
Product name: 2-Chloro-4-fluoro-5-nitrophenol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C585080
Product name: 2-Chloro-4-fluoro-5-nitrophenol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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2-Chloro-4-fluoro-5-nitrophenol Chemical Properties,Usage,Production

Synthesis

84478-89-7

84478-75-1

2-Chloro-4-fluoro-5-nitrophenyl methyl carbonate (120 g, 0.48 mol) was mixed with sodium hydroxide (22.7 g, 0.57 mol) in water (300 mL) and the reaction was carried out at reflux for 4 hrs. Upon completion of the reaction, the insoluble solids were removed by filtration and the filtrate was acidified with dilute hydrochloric acid to pH < 7. Subsequently, the precipitated solid product was collected by filtration, washed with water and dried to afford 2-chloro-4-fluoro-5-nitrophenol (90 g, 98% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.18 (s, 1H), 8.10 (d, J=10.4 Hz, 1H), 7.62 (d, J=7.2 Hz, 1H); mass spectrum (ESI) m/z: 192.1 ([M+H]+).

References

[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 38
[2] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 75
[3] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00252
[4] Organic Process Research and Development, 2014, vol. 18, # 1, p. 122 - 134
[5] Patent: US2008/234267, 2008, A1. Location in patent: Page/Page column 15

2-Chloro-4-fluoro-5-nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

FLUMICLORAC-PENTYL

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2-Chloro-4-fluoro-5-nitrophenol Suppliers

Americas 1 China 159 Europe 3 France 1 Germany 2 India 4 Italy 1 Japan 1 United Kingdom 15 United States 32 Global 219

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View Lastest Price from 2-Chloro-4-fluoro-5-nitrophenol manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-fluoro-5-nitrophenol 84478-75-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-07

84478-75-1, 2-Chloro-4-fluoro-5-nitrophenolRelated Search:

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84478-75-1

C6H3ClFNO3

C6H3NO3ClF

Phenyls & Phenyl-Het

Phenol&Thiophenol&Mercaptan

API intermediates

Phenyls & Phenyl-Het