2-chloro-5-(difluoroMethoxy)pyridine
- Product Name
- 2-chloro-5-(difluoroMethoxy)pyridine
- CAS No.
- 1206980-28-0
- Chemical Name
- 2-chloro-5-(difluoroMethoxy)pyridine
- Synonyms
- 2-chloro-5-(difluoroMethoxy)pyridine;Pyridine, 2-chloro-5-(difluoromethoxy)-
- CBNumber
- CB12664966
- Molecular Formula
- C6H4ClF2NO
- Formula Weight
- 179.55
- MOL File
- 1206980-28-0.mol
2-chloro-5-(difluoroMethoxy)pyridine Property
- Boiling point:
- 208.8±35.0 °C(Predicted)
- Density
- 1.382±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -3.29±0.10(Predicted)
- form
- liquid
- color
- Clear, colourless
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C382813
- Product name
- 2-Chloro-5-(difluoromethoxy)pyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC421027
- Product name
- 2-Chloro-5-(difluoromethoxy)pyridine
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 1800AQ
- Product name
- 2-chloro-5-(difluoromethoxy)pyridine
- Packaging
- 100mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- PC421027
- Product name
- 2-Chloro-5-(difluoromethoxy)pyridine
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 4H07-7-49
- Product name
- 2-Chloro-5-(difluoromethoxy)pyridine
- Packaging
- 1g
- Price
- $317
- Updated
- 2021/12/16
2-chloro-5-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production
Synthesis
41288-96-4
1885-46-7
1206980-28-0
GENERAL METHOD: To a vigorously stirred solution of 2-chloro-5-hydroxypyridine (0.13 g, 1.0 mmol) in acetonitrile (2 mL) was slowly added an aqueous solution of 6 M potassium hydroxide (2 mL) at room temperature. Subsequently, difluoromethyl trifluoromethanesulfonate (0.38 mL, 3.0 mmol, 3 eq.) was added dropwise to the reaction mixture while the reaction temperature was controlled by a water bath to maintain room temperature (note that the reaction is exothermic). Stirring of the reaction mixture was continued for 30 minutes. Upon completion of the reaction, the mixture was diluted with distilled water (20 mL) and extracted sequentially with ether (2 × 10 mL) and ethyl acetate (3 × 10 mL). All organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a gradient elution of pentane/diethyl ether (100:0 to 70:30, v/v) to give pure 2-chloro-5-difluoromethoxypyridine.
References
[1] Journal of Fluorine Chemistry, 2017, vol. 203, p. 155 - 165
2-chloro-5-(difluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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