2-broMo-5-(difluoroMethoxy)pyridine

Product Name: 2-broMo-5-(difluoroMethoxy)pyridine
CAS No.: 845827-14-7
Chemical Name: 2-broMo-5-(difluoroMethoxy)pyridine
Synonyms: 2-Bromo-5-(difluoromethoxy);2-broMo-5-(difluoroMethoxy)pyridine;Pyridine,2-bromo-5-(difluoromethoxy)-
CBNumber: CB32663802
Molecular Formula: C6H4BrF2NO
Formula Weight: 224
MOL File: 845827-14-7.mol

More

Less

2-broMo-5-(difluoroMethoxy)pyridine Property

Boiling point:: 235.2±35.0 °C(Predicted)
Density: 1.670±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.29±0.10(Predicted)
form: liquid
color: Pale yellow

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B292505
Product name: 2-Bromo-5-(difluoromethoxy)pyridine
Packaging: 250mg
Price: $330
Updated: 2021/12/16

Apolloscientific

Product number: PC421030
Product name: 2-Bromo-5-(difluoromethoxy)pyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-9-42
Product name: 2-Bromo-5-(difluoromethoxy)pyridine
Packaging: 500mg
Price: $104
Updated: 2021/12/16

Apolloscientific

Product number: PC421030
Product name: 2-Bromo-5-(difluoromethoxy)pyridine
Packaging: 1g
Price: $112
Updated: 2021/12/16

AK Scientific

Product number: 7659DA
Product name: 2-Bromo-5-(difluoromethoxy)pyridine
Packaging: 100mg
Price: $154
Updated: 2021/12/16

More

Less

2-broMo-5-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

55717-45-8

1895-39-2

845827-14-7

Using 6-bromopyridin-3-ol (1.2 g, 6.9 mmol) and sodium difluorochloroacetate (2.1 g, 13.8 mmol) as raw materials, potassium carbonate (1.24 g, 8.97 mmol) was added in anhydrous DMF (10 ml) and the mixture was stirred and reacted for 20 hrs at 80 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was partitioned between EtOAc and water. The aqueous layer was back-extracted with EtOAc, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by chromatography on a Redi-Sep pre-populated silica gel column (40 g) using a gradient elution with hexane solution from 0 to 10% EtOAc to afford 2-bromo-5-difluoromethoxypyridine (0.89 g, 4.0 mmol, 58% yield) as a colorless oil.ESI-MS (M+1) m/z: 225.8.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 23, p. 8421 - 8439
[2] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0902
[3] Patent: EP1741703, 2007, A1. Location in patent: Page/Page column 73
[4] Patent: US2018/37594, 2018, A1. Location in patent: Paragraph 0280-0283
[5] Patent: US2014/249104, 2014, A1. Location in patent: Page/Page column

2-broMo-5-(difluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-broMo-5-(difluoroMethoxy)pyridine Suppliers

China 53 India 1 United Kingdom 1 United States 5 Global 60

Shanghai potentpharm CO.,Ltd

Tel: 13524892556
Fax: (86) 21 51969655， QQ： 263541193
Email: sales-cn@potentpharm.com
Country: China
ProdList: 1011
Advantage: 55

Aloespharm Co., Ltd.

Tel: 021-20960837
Fax: 021-20960837
Email: market@aloespharm.com
Country: China
ProdList: 1302
Advantage: 55

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3014
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

845827-14-7, 2-broMo-5-(difluoroMethoxy)pyridineRelated Search:

2-chloro-4-(difluoroMethoxy)pyridine 2-chloro-6-(difluoroMethoxy)pyridine 2-chloro-3-(difluoroMethoxy)pyridine 2-chloro-5-(difluoroMethoxy)pyridine

2-broMo-5-(difluoroMethoxy)pyridine

Pyridine,2-bromo-5-(difluoromethoxy)-

2-Bromo-5-(difluoromethoxy)

845827-14-7