ChemicalBook > CAS DataBase List > CP 809101 hydrochloride

CP 809101 hydrochloride

Product Name: CP 809101 hydrochloride
CAS No.: 1215721-40-6
Chemical Name: CP 809101 hydrochloride
Synonyms: CP-809101 HCl;CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE;2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine;2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride;2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1);CP 809101 hydrochloride,hyperactivity,nicotine dependence,Inhibitor,nicotine,antipsychotic,inhibit,CP-809101,Serotonin Receptor,5-HT Receptor,CP809101,conditioned avoidance responding,CP 809101,CP809101 hydrochloride,5-hydroxytryptamine Receptor
CBNumber: CB12666612
Molecular Formula: C15H18Cl2N4O
Formula Weight: 341.23562
MOL File: 1215721-40-6.mol

Less

CP 809101 hydrochloride Property

storage temp.: Store at -20°C
solubility: H2O : 20 mg/mL (58.61 mM; Need ultrasonic)
form: Powder
color: Light yellow to yellow

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

TRC

Product number: C781443
Product name: CP809101Hydrochloride
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC64988
Product name: CP 809101 hydrochloride
Packaging: 50mg
Price: $298
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC64988
Product name: CP 809101 hydrochloride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-1221
Product name: CP-809101hydrochloride
Purity: 99.83%
Packaging: 10mg
Price: $134
Updated: 2021/12/16

AK Scientific

Product number: 2524DN
Product name: 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazinehydrochloride
Packaging: 10mg
Price: $164
Updated: 2021/12/16

Less

CP 809101 hydrochloride Chemical Properties,Usage,Production

Uses

CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].

in vivo

CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner^[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)^[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED₅₀ value of 2.2 mg/kg^[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine^[2].

Animal Model:	Male CF rats (conditioned avoidance responding (CAR) model)^[1].
Dosage:	0.1-56 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID₅₀ value of 4.8 mg/kg.

Animal Model:	Male CD rats (PCP or d-amphetamine-induced hyperactivity model)^[1].
Dosage:	0.56, 1.78, 5.6, 17.8 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Antagonized PCP-induced hyperactivity, with an ED₅₀ value of 2.4 mg/kg. Antagonized d-amphetamine-induced hyperactivity, with an ED₅₀ value of 2.7 mg/kg, and in a dose-dependent manner.

Animal Model:	Male CD rats (spontaneous locomotor model)^[1].
Dosage:	0.56, 1.78, 5.6, 17.8 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Inhibited spontaneous locomotor activity in a dose-dependent manner (ED₅₀=2.7 mg/kg).

Animal Model:	Adult male Sprague-Dawley rats (280-400 g)^[2].
Dosage:	0.3, 1, 3 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Produced a dose-related decrease in responding for food and nicotine self-administration in rats.

IC 50

5-HT_2C Receptor: 9.96 (pEC₅₀); 5-HT_2B Receptor: 7.19 (pEC₅₀); 5-HT_2A Receptor: 6.81 (pEC₅₀)

storage

Desiccate at RT

References

[1] Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. DOI:10.1016/j.neuropharm.2006.07.024
[2] Higgins GA, et al. Evaluation of chemically diverse 5-HT?c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. DOI:10.1007/s00213-012-2919-2

CP 809101 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CP 809101 hydrochloride Suppliers

China 41 United Kingdom 2 United States 10 Global 53

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4809
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 942
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Tel: 025-58851090 17714375163
Email: 2881759498@qq.com
Country: China
ProdList: 13011
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11146
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Country: China
ProdList: 892
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

Guangzhou Xinghe Biotechnology Co., Ltd.

Tel: 15889822182
Country: CHINA
ProdList: 160
Advantage: 58

Kunming Shengyuan Technology Co., Ltd

Tel: 18987584767
Country: CHINA
ProdList: 165
Advantage: 58

Shanghai Shitang Industrial Co., Ltd.

Tel: 17301778918
Country: CHINA
ProdList: 105
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Carbosynth China Ltd.

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: China
ProdList: 6532
Advantage: 50

1215721-40-6, CP 809101 hydrochlorideRelated Search:

4-Methoxyphenylacetone Cinnamyl alcohol 1-(2-BROMOPHENYL)-2-THIOUREA 4-Methoxybenzylchloride 3-Chloropropionyl chloride

2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1)

CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE

CP-809101 HCl

2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine

CP 809101 hydrochloride,hyperactivity,nicotine dependence,Inhibitor,nicotine,antipsychotic,inhibit,CP-809101,Serotonin Receptor,5-HT Receptor,CP809101,conditioned avoidance responding,CP 809101,CP809101 hydrochloride,5-hydroxytryptamine Receptor

2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride

1215721-40-6

C15H17ClN4OHCl