ChemicalBook > CAS DataBase List > OTSSP 167 hydrochloride

OTSSP 167 hydrochloride

Product Name
OTSSP 167 hydrochloride
CAS No.
1431697-89-0
Chemical Name
OTSSP 167 hydrochloride
Synonyms
OTS167;CS-1832;CS-1147;OTSSP167;OTSSP 167;OTSSP-167;MELK inhibitor;OTSSP167 (OTS167);OTSSP167 (CS-1147);OTSSP167 (Free base)
CBNumber
CB12666672
Molecular Formula
C25H28Cl2N4O2
Formula Weight
487.42
MOL File
1431697-89-0.mol
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OTSSP 167 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
O713000
Product name
OTSSP167
Packaging
2.5mg
Price
$165
Updated
2021/12/16
AK Scientific
Product number
2618AH
Product name
1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
Packaging
2mg
Price
$232
Updated
2021/12/16
ApexBio Technology
Product number
B1321
Product name
OTSSP167
Packaging
10mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
2618AH
Product name
1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
Packaging
10mg
Price
$424
Updated
2021/12/16
Biosynth Carbosynth
Product number
BO170790
Product name
OTS 167
Packaging
50mg
Price
$472.5
Updated
2021/12/16
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OTSSP 167 hydrochloride Chemical Properties,Usage,Production

Uses

OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor.

Definition

ChEBI: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichloro-1-cyclohexa-2,5-dienone is a naphthyridine derivative.

Biological Activity

otssp167 is an inhibitor of maternal embryonic leucine zipper kinase (melk) with ic50 value of 0.41nm [1].melk is a member of the ampk serine/threonine kinase family and is involved in the mammalian embryonic development. it plays roles in cancer cell growth and formation or maintenance of cancer stem cells. otssp167 is a small-molecule inhibitor and can inhibit melk’s activity effectively and selectively. otssp167 inhibits cell proliferation of a variety of cancer cell lines including a549, t47d, du4475 and 22rv1. the ic50 values are 6.7nm, 4.3nm, 2.3nm and 6nm, respectively. in mice bearing mda-mb-231 xenograft, administration of otssp167 inhibits 70% tumor growth at dose of 20 mg/kg. besides that, otssp167 is also found to have effects on psma1 and dbnl which are the novel substrates of melk. it inhibits the phosphorylation of psma1 and dbnl causes the subsequent suppression of mammosphere formation [1].

target

MELK

References

[1] chung s, suzuki h, miyamoto t, et al. development of an orally-administrative melk-targeting inhibitor that suppresses the growth of various types of human cancer. oncotarget, 2012, 3(12): 1629.

OTSSP 167 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OTSSP 167 hydrochloride manufacturers

Career Henan Chemical Co
Product
OTSSP167 1431697-89-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

1431697-89-0, OTSSP 167 hydrochlorideRelated Search:

Dichloroethane Thionyl chloride Xylene Bortezomib Selumetinib VE-821 Crizotinib AZD-9291 Olaparib

  • MELK inhibitor
  • OTSSP 167 hydrochloride
  • OTSSP167 (hydrochloride)
  • OTSSP-167 hydrochloride
  • OTSSP 167
  • OTSSP167
  • OTSSP-167
  • CS-1832
  • 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
  • OTSSP167 (CS-1147)
  • OTSSP167 (Free base)
  • CS-1147
  • 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone
  • OTS167
  • 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((1r,4r)-4-((dimethylamino)methyl)cyclohexylamino)-1,5-naphthyridin-3-yl)ethanone
  • 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone OTSSP167 hcl
  • Ethanone, 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-
  • OTSSP167 (OTS167)
  • inhibit,Maternal embryonic leucine zipper kinase,OTS 167,Inhibitor,OTS-167,MELK,OTSSP167,OTSSP 167,OTSSP-167
  • 1431697-89-0
  • C25H28Cl2N4O2
  • Inhibitors
  • API