GKA-50
- Product Name
- GKA-50
- CAS No.
- 851884-87-2
- Chemical Name
- GKA-50
- Synonyms
- GKA50;GKA-50;GKA 50;GKA-50; GKA 50;OCBMECSFDVUYQN-ROUUACIJSA-N;6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid;3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-
- CBNumber
- CB12667462
- Molecular Formula
- C26H28N2O6
- Formula Weight
- 464.51
- MOL File
- 851884-87-2.mol
GKA-50 Property
- Boiling point:
- 607.0±55.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 3.49±0.10(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0849
- Product name
- GKA50
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $203
- Updated
- 2025/07/31
- Product number
- SML0849
- Product name
- GKA50
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $670
- Updated
- 2025/07/31
- Product number
- 5133
- Product name
- GKA50
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $284
- Updated
- 2021/12/16
- Product number
- 255377
- Product name
- GKA 50
- Packaging
- 10mg
- Price
- $593
- Updated
- 2021/12/16
- Product number
- M264215
- Product name
- 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid
- Packaging
- 100mg
- Price
- $6325
- Updated
- 2021/12/16
GKA-50 Chemical Properties,Usage,Production
Uses
6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
Biological Activity
GKA50 is a specific activator of glucokinase (EC50 = 0.03 μM). In mouse MIN6 insulin-secreting cells and r at pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.
in vivo
GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test[1].
| Animal Model: | High-fat-fed obese female Zucker (fa/fa) rats[1] |
| Dosage: | 1, 3, 10, 30?mg/kg |
| Administration: | Oral administration |
| Result: | Significant percentage glucose lowering. |
storage
Store at -20°C
GKA-50 Preparation Products And Raw materials
Raw materials
Preparation Products
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