N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide

ChemicalBook > CAS DataBase List > N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide

N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide

Product Name: N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
CAS No.: 1314891-22-9
Chemical Name: N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
Synonyms: TFMO 2;TMP 195;CS-2651;TMP195; TMP-195;TMP 195 - TFMO 2;TMP-195;TMP195;TMP 195;Inhibitor,TMP195,TMP-195,HDAC,Histone deacetylases,inhibit;N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide;Benzamide, N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
CBNumber: CB12667558
Molecular Formula: C23H19F3N4O3
Formula Weight: 456.42
MOL File: 1314891-22-9.mol

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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Property

Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form: A crystalline solid
pka: 13.05±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23242
Product name: TMP-195
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23242
Product name: TMP-195
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 23242
Product name: TMP-195
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 23242
Product name: TMP-195
Purity: ≥98%
Packaging: 25mg
Price: $571
Updated: 2024/03/01

ChemScene

Product number: CS-7000
Product name: TMP195
Purity: 99.68%
Packaging: 50mg
Price: $792
Updated: 2021/12/16

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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Chemical Properties,Usage,Production

Biological Activity

TMP195 (TFMO 2) is a selective class IIa HDAC inhibitor with IC50 of 300 nM in cell-based assays.

in vitro

TMP195 has low potency in recombinant class I and class IIb HDAC assays, and is able to completely inhibit class IIa HDAC activity without inhibiting other HDACs. In the supernatant of monocyte-derived macrophage differentiation medium, it prevented the accumulation of CCL2 protein; compared with the control group, it could significantly increase the level of CCL1 protein secreted by monocytes.

target

Target	Value
HDAC9 (Cell-free assay)	15 nM(Ki)
HDAC7 (Cell-free assay)	26 nM(Ki)
HDAC4 (Cell-free assay)	59 nM(Ki)
HDAC5 (Cell-free assay)	60 nM(Ki)

N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Suppliers

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1314891-22-9, N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMideRelated Search:

TMP269 TMP778

TMP-195;TMP195;TMP 195

CS-2651

TFMO 2

N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide

TMP 195

TMP 195 - TFMO 2

TMP195; TMP-195

Inhibitor,TMP195,TMP-195,HDAC,Histone deacetylases,inhibit

Benzamide, N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

1314891-22-9

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