ChemicalBook > CAS DataBase List > N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
- Product Name
- N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
- CAS No.
- 1314891-22-9
- Chemical Name
- N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
- Synonyms
- TFMO 2;TMP 195;CS-2651;TMP195; TMP-195;TMP 195 - TFMO 2;TMP-195;TMP195;TMP 195;Inhibitor,TMP195,TMP-195,HDAC,Histone deacetylases,inhibit;N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide;Benzamide, N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
- CBNumber
- CB12667558
- Molecular Formula
- C23H19F3N4O3
- Formula Weight
- 456.42
- MOL File
- 1314891-22-9.mol
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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Property
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.2 mg/ml
- form
- A crystalline solid
- pka
- 13.05±0.46(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 23242
- Product name
- TMP-195
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23242
- Product name
- TMP-195
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23242
- Product name
- TMP-195
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23242
- Product name
- TMP-195
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $571
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-7000
- Product name
- TMP195
- Purity
- 99.68%
- Packaging
- 50mg
- Price
- $792
- Updated
- 2021/12/16
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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Chemical Properties,Usage,Production
Biological Activity
TMP195 (TFMO 2) is a selective class IIa HDAC inhibitor with IC50 of 300 nM in cell-based assays.
in vitro
TMP195 has low potency in recombinant class I and class IIb HDAC assays, and is able to completely inhibit class IIa HDAC activity without inhibiting other HDACs. In the supernatant of monocyte-derived macrophage differentiation medium, it prevented the accumulation of CCL2 protein; compared with the control group, it could significantly increase the level of CCL1 protein secreted by monocytes.
target
| Target | Value |
| HDAC9 (Cell-free assay) | 15 nM(Ki) |
| HDAC7 (Cell-free assay) | 26 nM(Ki) |
| HDAC4 (Cell-free assay) | 59 nM(Ki) |
| HDAC5 (Cell-free assay) | 60 nM(Ki) |
N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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