PCI 29732
- Product Name
- PCI 29732
- CAS No.
- 330786-25-9
- Chemical Name
- PCI 29732
- Synonyms
- CS-2698;PCI 29732;PCI 29732, 10 mM in DMSO;PCI 29732;PCI29732;PCI-29732;PCI 29732 (This product is only available in Japan.);1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;4-Amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-;cytotoxicity,Bruton tyrosine kinase,Inhibitor,Btk,ABCG2,reversible,PCI 29732,BCR,inhibit,B-cell,BCRP,oral,Breast cancer resistance protein
- CBNumber
- CB12668434
- Molecular Formula
- C22H21N5O
- Formula Weight
- 371.43
- MOL File
- 330786-25-9.mol
PCI 29732 Property
- Boiling point:
- 599.6±50.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- pka
- 4.24±0.30(Predicted)
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29036
- Product name
- PCI-29732
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29036
- Product name
- PCI-29732
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 29036
- Product name
- PCI-29732
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 29036
- Product name
- PCI-29732
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 5012
- Product name
- PCI29732
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $207
- Updated
- 2021/12/16
PCI 29732 Chemical Properties,Usage,Production
Uses
PCI 29732 (cas# 330786-25-9) is a useful research chemical. It is a COVID19-related research product.
Definition
ChEBI: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an aromatic ether.
in vivo
PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents[2].
PCI 29732 (20 mg/kg; p.o.; every 3 d × 5 times) enhances the anticancer efficacy of Topotecan in the H460/MX20 cell xenograft nude mice model[2].
| Animal Model: | 5-6 weeks old athymic nude mice (bearing H460/MX20 cells)[2] |
| Dosage: | 20 mg/kg (combination with Topotecan; every 3 d × 5 times, i.p., 3 mg/kg; topotecan was given 1 h after PCI29732 administration) |
| Administration: | P.o.; every 3 d × 5 times |
| Result: | Significant reductions in tumor weight and volume were observed in the group treated with PCI29732 in combination with Topotecan. |
storage
Store at +4°C
PCI 29732 Preparation Products And Raw materials
Raw materials
Preparation Products
PCI 29732 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77