ChemicalBook > CAS DataBase List > OG-L002

OG-L002

Product Name: OG-L002
CAS No.: 1357302-64-7
Chemical Name: OG-L002
Synonyms: CS-830;OG-L002;OG-L002 USP/EP/BP;OG-L002, 10 mM in DMSO;OGL002;OG L002;OGL-002;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
CBNumber: CB12677399
Molecular Formula: C15H15NO
Formula Weight: 225.29
MOL File: 1357302-64-7.mol

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OG-L002 Property

Boiling point:: 416.7±45.0 °C(Predicted)
Density: 1.193±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
form: solid
pka: 9.78±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17471
Product name: OG-L002
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 17471
Product name: OG-L002
Purity: ≥98%
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 17471
Product name: OG-L002
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 17471
Product name: OG-L002
Purity: ≥98%
Packaging: 25mg
Price: $553
Updated: 2024/03/01

Tocris

Product number: 6244
Product name: OG-L002
Purity: ≥98%(HPLC)
Packaging: 25
Price: $450
Updated: 2021/12/16

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OG-L002 Chemical Properties,Usage,Production

Description

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC₅₀ = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC₅₀s = 1.38 and 0.72 μM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

Uses

OG-L002 is a novel, potent, and selective LSD1/KDM1A inhibitor that epigenetically blocks the herpes simplex lytic replication and reactivation from latency.

in vivo

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection^[1].

Animal Model:	4-week-old BALB/c female mice^[1]
Dosage:	6, 20, 40 mg/kg
Administration:	Intraperitoneal; daily; for 7 days
Result:	Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.

target

LSD1

storage

Store at -20°C

References

[1] FEDERICO FORNERIS. Human histone demethylase LSD1 reads the histone code.[J]. The Journal of Biological Chemistry, 2005, 280 50: 41360-41365. DOI: 10.1074/jbc.m509549200
[2] YU LIANG. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.[J]. mBio, 2013, 4 1: e00558-12. DOI: 10.1128/mbio.00558-12

OG-L002 Preparation Products And Raw materials

Raw materials

Preparation Products

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OG-L002 Suppliers

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1357302-64-7, OG-L002Related Search:

Tazemetostat BIX 01294 GSK J4 HCl 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol MM-102

OG-L002

[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o

OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-

OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol

OGL002;OG L002;OGL-002

CS-830

4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol

4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol

[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-

OG-L002 USP/EP/BP

OG-L002, 10 mM in DMSO

1357302-64-7

Inhibitors