MM-102
- Product Name
- MM-102
- CAS No.
- 1417329-24-8
- Chemical Name
- MM-102
- Synonyms
- MM-102;CS-2007;MM-102 MM102;MM-102 TFA Salt;MM-102 USP/EP/BP;HMTase Inhibitor IX;HMTASE INHIBITOR IX;MM102;MM 102;MM-102;MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase;(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide;1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]
- CBNumber
- CB32702891
- Molecular Formula
- C35H49F2N7O4
- Formula Weight
- 669.8
- MOL File
- 1417329-24-8.mol
MM-102 Property
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
- form
- Powder
- pka
- 12.90±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17699
- Product name
- MM-102
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17699
- Product name
- MM-102
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 17699
- Product name
- MM-102
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 17699
- Product name
- MM-102
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 5307
- Product name
- MM102
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $278
- Updated
- 2021/12/16
MM-102 Chemical Properties,Usage,Production
Uses
MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.
Biological Activity
mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].
target
MLL1
References
[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.
MM-102 Preparation Products And Raw materials
Raw materials
Preparation Products
MM-102 Suppliers
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- 0571-85350119 15888826472
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- China
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- 86-21-57758967
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- China
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- 051085625359
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- China
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- 025-58849295 18951903616;
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- 025-68650336
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- China
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- 027-59599241 18871490274
- Fax
- 027-59599241
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- China
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- +86-21-5821 5861
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- +86-21-5106 2861
- sales@letopharm.com
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- China
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- +86-21-52996696
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- Tel
- Fax
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- eric_feng1954@126.com
- Country
- China
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View Lastest Price from MM-102 manufacturers
- Product
- MM-102 1417329-24-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06