MM-102

Product Name: MM-102
CAS No.: 1417329-24-8
Chemical Name: MM-102
Synonyms: MM-102;CS-2007;MM-102 MM102;MM-102 TFA Salt;MM-102 USP/EP/BP;HMTase Inhibitor IX;HMTASE INHIBITOR IX;MM102;MM 102;MM-102;MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase;(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide;1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]
CBNumber: CB32702891
Molecular Formula: C35H49F2N7O4
Formula Weight: 669.8
MOL File: 1417329-24-8.mol

More

Less

MM-102 Property

Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
form: Powder
pka: 12.90±0.20(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Tocris

Product number: 5307
Product name: MM102
Purity: ≥98%(HPLC)
Packaging: 10
Price: $278
Updated: 2021/12/16

More

Less

MM-102 Chemical Properties,Usage,Production

Uses

MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.

Biological Activity

mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].

target

MLL1

References

[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.

MM-102 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MM-102 Suppliers

China 68 India 1 United States 14 Global 83

Hangzhou Baige Pharmaceutical Technology Co. , Ltd.

Tel: 0571-85350119 15888826472
Email: 15888826472@163.com
Country: China
ProdList: 2729
Advantage: 58

Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 15888826472
Email: bptsales@163.com
Country: China
ProdList: 3851
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4566
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

More

Less

View Lastest Price from MM-102 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: MM-102 1417329-24-8
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

1417329-24-8, MM-102Related Search:

2-(4-Isopropylpheny)-4H-chroMen-4-one BIX 01294 Tazemetostat (EPZ-6438) GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol OG-L002

CS-2007

HMTASE INHIBITOR IX;MM102;MM 102;MM-102

MM-102

Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-

HMTase Inhibitor IX

1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]

MM-102 TFA Salt

MM-102 USP/EP/BP

MM-102 MM102

MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase

(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide

1417329-24-8

C35H49F2N7O4

Inhibitors