ChemicalBook > CAS DataBase List > MM-102

MM-102

Product Name
MM-102
CAS No.
1417329-24-8
Chemical Name
MM-102
Synonyms
MM-102;CS-2007;MM-102 MM102;MM-102 TFA Salt;MM-102 USP/EP/BP;HMTase Inhibitor IX;HMTASE INHIBITOR IX;MM102;MM 102;MM-102;MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase;(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide;1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]
CBNumber
CB32702891
Molecular Formula
C35H49F2N7O4
Formula Weight
669.8
MOL File
1417329-24-8.mol
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MM-102 Property

Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
form 
Powder
pka
12.90±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17699
Product name
MM-102
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17699
Product name
MM-102
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17699
Product name
MM-102
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
17699
Product name
MM-102
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
Tocris
Product number
5307
Product name
MM102
Purity
≥98%(HPLC)
Packaging
10
Price
$278
Updated
2021/12/16
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MM-102 Chemical Properties,Usage,Production

Uses

MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.

Biological Activity

mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].

target

MLL1

References

[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.

MM-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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MM-102 Suppliers

China 68 India 1 United States 14 Global 83
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
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View Lastest Price from MM-102 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
MM-102 1417329-24-8
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06

1417329-24-8, MM-102Related Search:

2-(4-Isopropylpheny)-4H-chroMen-4-one BIX 01294 Tazemetostat (EPZ-6438) GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol OG-L002

  • CS-2007
  • HMTASE INHIBITOR IX;MM102;MM 102;MM-102
  • MM-102
  • Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-
  • HMTase Inhibitor IX
  • 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]
  • MM-102 TFA Salt
  • MM-102 USP/EP/BP
  • MM-102 MM102
  • MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase
  • (S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide
  • 1417329-24-8
  • C35H49F2N7O4
  • Inhibitors