ChemicalBook > CAS DataBase List > MM-102

MM-102

Product Name: MM-102
CAS No.: 1417329-24-8
Chemical Name: MM-102
Synonyms: MM-102;CS-2007;MM-102 MM102;MM-102 TFA Salt;MM-102 USP/EP/BP;HMTase Inhibitor IX;MM-102, 10 mM in DMSO;MM-102 (HMTase Inhibitor IX);HMTASE INHIBITOR IX;MM102;MM 102;MM-102;MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase
CBNumber: CB32702891
Molecular Formula: C35H49F2N7O4
Formula Weight: 669.8
MOL File: 1417329-24-8.mol

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MM-102 Property

Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
form: Powder
pka: 12.90±0.20(Predicted)
color: White to off-white
InChIKey: RZKSQRIPRKWVBU-MHZLTWQESA-N
SMILES: C1(NC(=O)[C@@H](NC(=O)C(CC)(NC(=O)C(C)C)CC)CCCNC(N)=N)(C(NC(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)=O)CCCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 17699
Product name: MM-102
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Tocris

Product number: 5307
Product name: MM102
Purity: ≥98%(HPLC)
Packaging: 10
Price: $278
Updated: 2021/12/16

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MM-102 Chemical Properties,Usage,Production

Uses

MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.

Biological Activity

mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].

in vivo

MM-102 (15 mg/kg; i.p.; once daily for 7 days) inhibits tumor progression in primary CCA model mice^[3]. MM-102 (15 mg/kg; i.p.; once daily for 7 days) inhibits p16INK4a gene expression in IRI mice and reduces renal fibrosis and renal inflammation in IRI mice^[4].

Animal Model:	Ischemia-reperfusion injury in mice^[4]
Dosage:	15 mg/kg
Administration:	i.p.; Once daily for 7 days
Result:	Inhibited a-SMA protein expression. Inhibited p-NF-kB (p65), IL-1b, TNF-a, and IL-6 mRNA expression.

target

MLL1

References

[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.

MM-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MM-102 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: MM-102 1417329-24-8
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

1417329-24-8, MM-102Related Search:

Tazemetostat 2-(4-Isopropylpheny)-4H-chroMen-4-one BIX 01294 GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol OG-L002

CS-2007

HMTASE INHIBITOR IX;MM102;MM 102;MM-102

MM-102

Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-

HMTase Inhibitor IX

1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]

MM-102 TFA Salt

MM-102 USP/EP/BP

MM-102 MM102

MM-102,Inhibitor,MM 102,inhibit,Histone Methyltransferase

(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide

MM-102 (HMTase Inhibitor IX)

MM-102, 10 mM in DMSO

1417329-24-8

C35H49F2N7O4

Inhibitors