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OG-L002

Product Name
OG-L002
CAS No.
1357302-64-7
Chemical Name
OG-L002
Synonyms
CS-830;OG-L002;OG-L002 USP/EP/BP;OGL002;OG L002;OGL-002;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
CBNumber
CB12677399
Molecular Formula
C15H15NO
Formula Weight
225.29
MOL File
1357302-64-7.mol
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OG-L002 Property

Boiling point:
416.7±45.0 °C(Predicted)
Density 
1.193±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
form 
solid
pka
9.78±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17471
Product name
OG-L002
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
17471
Product name
OG-L002
Purity
≥98%
Packaging
5mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
17471
Product name
OG-L002
Purity
≥98%
Packaging
10mg
Price
$274
Updated
2024/03/01
Cayman Chemical
Product number
17471
Product name
OG-L002
Purity
≥98%
Packaging
25mg
Price
$553
Updated
2024/03/01
Tocris
Product number
6244
Product name
OG-L002
Purity
≥98%(HPLC)
Packaging
25
Price
$450
Updated
2021/12/16
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OG-L002 Chemical Properties,Usage,Production

Description

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 μM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

Uses

OG-L002 is a novel, potent, and selective LSD1/KDM1A inhibitor that epigenetically blocks the herpes simplex lytic replication and reactivation from latency.

target

LSD1

storage

Store at -20°C

OG-L002 Preparation Products And Raw materials

Raw materials

Preparation Products

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OG-L002 Suppliers

China 86 India 2 United Kingdom 1 United States 10 Global 99
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Hygeia (Chengdu) pharmaceutical technique Co., Ltd
Tel
028-84502008 13568869383
Fax
028-66476329
Email
sales@hygeiapharm.com
Country
China
ProdList
293
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4121
Advantage
55
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58

1357302-64-7, OG-L002Related Search:

BIX 01294 Tazemetostat (EPZ-6438) GSK J4 HCl 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol MM-102

  • OG-L002
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o
  • OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
  • OGL002;OG L002;OGL-002
  • CS-830
  • 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol
  • 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • OG-L002 USP/EP/BP
  • 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
  • 1357302-64-7
  • Inhibitors