SF1670(PTENinhibitor)
- Product Name
- SF1670(PTENinhibitor)
- CAS No.
- 345630-40-2
- Chemical Name
- SF1670(PTENinhibitor)
- Synonyms
- SF1670;CS-1143;SF 1670;SF-1670;PTP CD45 Inhibitor;SF1670 >=98% (HPLC);SF1670(PTENinhibitor);6-PHENYL-2-(2-PYRAZINYL)-4(1H)-PYRIMIDINONE;PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem;N-(9,10-Dioxo-9,10-dihydro-2-phenanthrenyl)-2,2-diMethylpropanaMide;N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
- CBNumber
- CB12681976
- Molecular Formula
- C19H17NO3
- Formula Weight
- 307.34
- MOL File
- 345630-40-2.mol
SF1670(PTENinhibitor) Property
- Boiling point:
- 554.1±29.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- Red-violet solid
- pka
- 14.31±0.20(Predicted)
- color
- light pink to red to very dark purple
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- SML0684
- Product name
- SF1670
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 540215
- Product name
- PTP CD45 Inhibitor
- Packaging
- 5mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 15368
- Product name
- SF1670
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15368
- Product name
- SF1670
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- SML0684
- Product name
- SF1670
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $951
- Updated
- 2023/01/07
SF1670(PTENinhibitor) Chemical Properties,Usage,Production
Uses
SF1670 has been used:
- To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
- To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
- To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.
Uses
SF1670 is used in the methods and compositions for treating tumor or cancer by administering to a subject a PTEN inhibitor and chemotherapeutic agents, immume dysregulation in patients with PTEN harmartoma tumor syndrome and analysis of FOXP3 regulatory T cells.
General Description
A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 μM for CD45 lck, >30 μM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 μM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
Biological Activity
sf1670 is a potent and specific inhibitor of pten [1].phosphatase and tensin homolog deleted on chromosome 10 (pten) is a phosphatidylinositol 3’-phosphatase that converts ptdins(3,4,5)p3 to phosphatidylinositol 4,5-bisphosphate. pten functions as a tumor suppressor that is mutated in many cancers [1].sf1670 is a potent and specific pten inhibitor. sf1670 bound to the active site of pten and increased ptdins(3,4,5)p3 signaling in neutrophils. in human neutrophils, sf1670 significantly increased akt phosphorylation stimulated by chemoattractant and specifically increased ptdins(3,4,5)p3 signaling. sf1670 efficiently increased akt phosphorylation at the concentration of 250nm. in mouse neutrophils, sf1670 also increased akt phosphorylation and ptdins(3,4,5)p3 signaling, which was mediated by the inhibition of pten activity. in neutrophils, sf1670 significantly increased reactive oxygen species (ros) production induced by fmlp. also, sf1670 increased neutrophil polarization induced by fmlp, which was necessary for the chemotactic migration and neutrophil recruitment to sites of inflammation [1].in a mouse neutropenia-associated bacterial pneumonia model, sf1670 increased the bacteria-killing capability and relieved inflammation-associated lung damage [1].
Biochem/physiol Actions
Cell permeable: yes
storage
Store at +4°C
References
[1]. li y, prasad a, jia y, et al. pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (pten) inhibitor sf1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. blood, 2011, 117(24): 6702-6713.
SF1670(PTENinhibitor) Preparation Products And Raw materials
Raw materials
Preparation Products
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