ChemicalBook > CAS DataBase List > SF1670(PTENinhibitor)

SF1670(PTENinhibitor)

Product Name
SF1670(PTENinhibitor)
CAS No.
345630-40-2
Chemical Name
SF1670(PTENinhibitor)
Synonyms
SF1670;CS-1143;SF 1670;SF-1670;PTP CD45 Inhibitor;SF1670 >=98% (HPLC);SF1670(PTENinhibitor);6-PHENYL-2-(2-PYRAZINYL)-4(1H)-PYRIMIDINONE;PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem;N-(9,10-Dioxo-9,10-dihydro-2-phenanthrenyl)-2,2-diMethylpropanaMide;N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
CBNumber
CB12681976
Molecular Formula
C19H17NO3
Formula Weight
307.34
MOL File
345630-40-2.mol
More
Less

SF1670(PTENinhibitor) Property

Boiling point:
554.1±29.0 °C(Predicted)
Density 
1.271±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
Red-violet solid
pka
14.31±0.20(Predicted)
color 
light pink to red to very dark purple
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0684
Product name
SF1670
Purity
≥98% (HPLC)
Packaging
5mg
Price
$243
Updated
2024/03/01
Sigma-Aldrich
Product number
540215
Product name
PTP CD45 Inhibitor
Packaging
5mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
15368
Product name
SF1670
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
15368
Product name
SF1670
Purity
≥98%
Packaging
5mg
Price
$141
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0684
Product name
SF1670
Purity
≥98% (HPLC)
Packaging
25mg
Price
$951
Updated
2023/01/07
More
Less

SF1670(PTENinhibitor) Chemical Properties,Usage,Production

Uses

SF1670 has been used:

  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Uses

SF1670 is used in the methods and compositions for treating tumor or cancer by administering to a subject a PTEN inhibitor and chemotherapeutic agents, immume dysregulation in patients with PTEN harmartoma tumor syndrome and analysis of FOXP3 regulatory T cells.

General Description

A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 μM for CD45 lck, >30 μM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 μM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.

Biological Activity

sf1670 is a potent and specific inhibitor of pten [1].phosphatase and tensin homolog deleted on chromosome 10 (pten) is a phosphatidylinositol 3’-phosphatase that converts ptdins(3,4,5)p3 to phosphatidylinositol 4,5-bisphosphate. pten functions as a tumor suppressor that is mutated in many cancers [1].sf1670 is a potent and specific pten inhibitor. sf1670 bound to the active site of pten and increased ptdins(3,4,5)p3 signaling in neutrophils. in human neutrophils, sf1670 significantly increased akt phosphorylation stimulated by chemoattractant and specifically increased ptdins(3,4,5)p3 signaling. sf1670 efficiently increased akt phosphorylation at the concentration of 250nm. in mouse neutrophils, sf1670 also increased akt phosphorylation and ptdins(3,4,5)p3 signaling, which was mediated by the inhibition of pten activity. in neutrophils, sf1670 significantly increased reactive oxygen species (ros) production induced by fmlp. also, sf1670 increased neutrophil polarization induced by fmlp, which was necessary for the chemotactic migration and neutrophil recruitment to sites of inflammation [1].in a mouse neutropenia-associated bacterial pneumonia model, sf1670 increased the bacteria-killing capability and relieved inflammation-associated lung damage [1].

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

[1]. li y, prasad a, jia y, et al. pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (pten) inhibitor sf1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. blood, 2011, 117(24): 6702-6713.

SF1670(PTENinhibitor) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SF1670(PTENinhibitor) Suppliers

China 87 India 1 The Netherlands 1 United Kingdom 1 United States 16 Global 106
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

345630-40-2, SF1670(PTENinhibitor)Related Search:

ANTI-SF1 SB 415286 ABT 737 Trametinib Crizotinib LY 294002 HYDROCHLORIDE Rapamycin

  • SF1670(PTENinhibitor)
  • N-(9,10-Dioxo-9,10-dihydro-2-phenanthrenyl)-2,2-diMethylpropanaMide
  • PTP CD45 Inhibitor
  • 6-PHENYL-2-(2-PYRAZINYL)-4(1H)-PYRIMIDINONE
  • SF1670
  • N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
  • PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem
  • SF 1670;SF-1670
  • CS-1143
  • Propanamide, N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-
  • SF1670 >=98% (HPLC)
  • 345630-40-2
  • Inhibitors