ChemicalBook > CAS DataBase List > 4-(di(1H-indol-3-yl)Methyl)phenol

4-(di(1H-indol-3-yl)Methyl)phenol

Product Name
4-(di(1H-indol-3-yl)Methyl)phenol
CAS No.
151358-47-3
Chemical Name
4-(di(1H-indol-3-yl)Methyl)phenol
Synonyms
C-DIM8;DIM-C-pPhOH;DIM-C-pPhOH(CDIM8);DIM-C-pPhOH, 10 mM in DMSO;4-(di(1H-indol-3-yl)Methyl)phenol;4-[bis(1H-indol-3-yl)methyl]phenol;Phenol, 4-(di-1H-indol-3-ylmethyl)-;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
CBNumber
CB12682261
Molecular Formula
C23H18N2O
Formula Weight
338.4
MOL File
151358-47-3.mol
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4-(di(1H-indol-3-yl)Methyl)phenol Property

Melting point:
122-124 °C
Boiling point:
610.2±50.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
form 
solid
pka
9.98±0.26(Predicted)
color 
Pink
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
6377
Product name
DIM-C-pPhOH
Purity
≥98%(HPLC)
Packaging
5
Price
$95
Updated
2021/12/16
Tocris
Product number
6377
Product name
DIM-C-pPhOH
Purity
≥98%(HPLC)
Packaging
25
Price
$371
Updated
2021/12/16
Matrix Scientific
Product number
105340
Product name
4-(Di(1H-indol-3-yl)methyl)phenol
Packaging
2g
Price
$975
Updated
2021/12/16
Chemenu
Product number
CM265482
Product name
4-(Di(1H-indol-3-yl)methyl)phenol
Purity
95%+
Packaging
5g
Price
$1234
Updated
2021/12/16
Alichem
Product number
151358473
Product name
4-(Di(1H-indol-3-yl)methyl)phenol
Packaging
5g
Price
$1306.8
Updated
2021/12/16
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4-(di(1H-indol-3-yl)Methyl)phenol Chemical Properties,Usage,Production

Description

C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5

storage

Store at -20°C

References

Chintharlapalli et al. (2005), Activation of Nur77 by selected 1,1-Bis(3’-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways; J. Biol. Chem., 280 24903 Lee et al. (2014), The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells; Mol. Cancer Res., 12 527 Lee et al. (2012), The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53; Oncogene, 31 3265 Hedrick et al. (2016), NR4A1 Antagonists Inhibit ?1-Integrin-Dependent Breast Cancer Cell Migration; Mol. Cell. Biol., 36 1383 Shrestha et al. (2021), The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells; Mol. Cancer Ther. 20 612

4-(di(1H-indol-3-yl)Methyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(di(1H-indol-3-yl)Methyl)phenol Suppliers

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151358-47-3, 4-(di(1H-indol-3-yl)Methyl)phenolRelated Search:

Levetiracetam NORFLUOXETINE HYDROCHLORIDE RESINIFERATOXIN Tigecycline Indole 2,3,3-Trimethylindolenine 1,3,3-Trimethyl-2-methyleneindoline

  • 4-(di(1H-indol-3-yl)Methyl)phenol
  • DIM-C-pPhOH
  • 4-[bis(1H-indol-3-yl)methyl]phenol
  • C-DIM8
  • 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
  • DIM-C-pPhOH(CDIM8)
  • Phenol, 4-(di-1H-indol-3-ylmethyl)-
  • inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
  • 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
  • DIM-C-pPhOH, 10 mM in DMSO
  • 151358-47-3