azepane-2,4-dione
Uses- Product Name
- azepane-2,4-dione
- CAS No.
- 29520-88-5
- Chemical Name
- azepane-2,4-dione
- Synonyms
- azepane-2,4-dione;1H-Tetrahydro-azepine-2,4-dione;1H-Azepine-2,4(3H,5H)-dione, dihydro-
- CBNumber
- CB12682892
- Molecular Formula
- C6H9NO2
- Formula Weight
- 127.14
- MOL File
- 29520-88-5.mol
azepane-2,4-dione Property
- Boiling point:
- 357.7±35.0 °C(Predicted)
- Density
- 1.122±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.68±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- A809763
- Product name
- Azepane-2,4-dione
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3822AJ
- Product name
- Azepane-2,4-dione
- Packaging
- 5g
- Price
- $1011
- Updated
- 2021/12/16
- Product number
- 3822AJ
- Product name
- Azepane-2,4-dione
- Packaging
- 10g
- Price
- $1692
- Updated
- 2021/12/16
- Product number
- A264150
- Product name
- Azepane-2,4-dione
- Purity
- 98%
- Packaging
- 100mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A264150
- Product name
- Azepane-2,4-dione
- Purity
- 98%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
azepane-2,4-dione Chemical Properties,Usage,Production
Uses
Azacycloheptan-2,4-dione can be used to prepare fused lactam derivatives having the following structure. These compounds exhibit antagonistic activity against serotonin 5-HT2A receptors and agonistic activity against serotonin 5-HT1A receptors, and can be used as drugs for the treatment of neuropsychiatric disorders.
Synthesis
165257-04-5
29520-88-5
Example 2A: Synthesis of benzyl-2,4-dione 4-Ethoxy-6,7-dihydro-1H-azepin-2(5H)-one (2.5 g, 16 mmol) was dissolved in acetone (70 mL) and 10% HCl aqueous solution (17 mL) was added. The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the acetone was removed under vacuum. The resulting mixture was extracted with dichloromethane (10 x 15 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give the crude product as a yellow solid. Purification by fast column chromatography (silica gel, 10% methanol/ethyl acetate) afforded azepane-2,4-dione (2.03 g, 100%) as a white solid. The product characterization data were as follows: 1H NMR (400 MHz, CDCl3) δ 7.55 (s, NH), 3.47 (s, 2H), 3.40 (m, ), 2.59 (t, J = 6.8 Hz, 2H), 1.96 (m, 2H). 13C NMR (100 MHz, CDCl3) δ 202.5, 169.5, 51.9, 43.2, 40.8, 27.6; IR (KBr) νm, 2.59 (t, J = 6.8 Hz, 2H), 1.96 (m, 2H). IR (KBr) νmax 3213, 3105, 2942, 1702, 1671, 1482, 1412, 1348 cm?1; HRMS (ESI) m/l; δ HRMS (ESI) m/z calculated C6H9NO2Na: 150.0525; measured: 150.0507.
References
[1] Organic Letters, 2009, vol. 11, # 10, p. 2133 - 2136
[2] Patent: US2010/234588, 2010, A1. Location in patent: Page/Page column 8
azepane-2,4-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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