ACT-132577

Product Name: ACT-132577
CAS No.: 1103522-45-7
Chemical Name: ACT-132577
Synonyms: ACT-132577;Aprocitentan;Depropylmethacetin;Despropyl Macitentan;Macitentan ACT-132577;N-Despropyl Macitentan;Macitentan Impurity 07;Macitentan ACT-132577-D4;D4-N-Despropyl Macitentan;Aprocitentan, 10 mM in DMSO
CBNumber: CB12685914
Molecular Formula: C16H14Br2N6O4S
Formula Weight: 546.19
MOL File: 1103522-45-7.mol

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ACT-132577 Property

Melting point:: 139-141°C
Boiling point:: 705.0±70.0 °C(Predicted)
Density: 1.841±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 13.56±0.60(Predicted)
color: White to Off-White
InChI: InChI=1S/C16H14Br2N6O4S/c17-11-3-1-10(2-4-11)13-14(24-29(19,25)26)22-9-23-15(13)27-5-6-28-16-20-7-12(18)8-21-16/h1-4,7-9H,5-6H2,(H2,19,25,26)(H,22,23,24)
InChIKey: DKULOVKANLVDEA-UHFFFAOYSA-N
SMILES: S(NC1C(C2=CC=C(Br)C=C2)=C(OCCOC2=NC=C(Br)C=N2)N=CN=1)(N)(=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 10mg
Price: $580
Updated: 2021/12/16

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 5mg
Price: $305
Updated: 2021/12/16

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 50mg
Price: $1635
Updated: 2021/12/16

ChemScene

Product number: CS-2687
Product name: Aprocitentan
Purity: 98.13%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

ChemScene

Product number: CS-2687
Product name: Aprocitentan
Purity: 98.13%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

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ACT-132577 Chemical Properties,Usage,Production

Uses

N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

Definition

ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

in vivo

Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat^[1]. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2%^[2].

IC 50

ET_A: 3.4 nM (IC₅₀); ET_A: 6.7 (pA2); ET_B: 987 nM (IC₅₀); ET_B: 5.5 (pA2)

ACT-132577 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACT-132577 Suppliers

China 163 France 1 India 4 United Kingdom 1 United States 10 Global 179

Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

Tel: 0551-68933033 13956024211
Fax: 0551-68935833
Email: trchem@163.com
Country: China
ProdList: 98
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 474
Advantage: 55

Jinan Jianfeng Chemical Co., Ltd.

Tel: 0531-88110457; 18954159893
Email: demi@pharmachemm.com
Country: China
ProdList: 190
Advantage: 58

NANJING WEDO PHARMATECH CO.,LTD.

Tel: 15189836218
Email: wedo-chem@huawe.com
Country: China
ProdList: 275
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Wuhan HSN Pharmaresearch CO., LTD.

Tel: 027-81525288 18086100502
Fax: 027-86589137
Email: linwell@126.com
Country: China
ProdList: 233
Advantage: 50

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 025-58741518 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 308
Advantage: 61

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View Lastest Price from ACT-132577 manufacturers

Nanjing Dorra Pharmaceutical Technology Co., Ltd

Product: Aprocitentan 1103522-45-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 0.99
Supply Ability: /
Release date: 2025-11-04

Jinan Jianfeng Chemical Co., Ltd

Product: Aprocitentan 1103522-45-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000
Release date: 2024-05-28

1103522-45-7, ACT-132577Related Search:

N-Despropyl Macitentan

Aprocitentan

5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE

ACT-132577

N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide

APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN

Despropyl Macitentan

Macitentan N-Despropyl Impurity

Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-

N-[5-(4-bromophenyl)-6-[2-(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl

Macitentan ACT-132577

5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine

Macitentan ACT-132577-D4

N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]aminosulfonamide

5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]sulfamide

Macitentan Impurity 07

Despropyl Macitentan (COLD SHIPMENT REQUIRED)

N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide

N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide , Aprocitentan

Aprocitentan, 10 mM in DMSO

N - [5- (4-bromophenyl) -6- [2- [(5-bromo-2-pyrimidinyl) oxy] ethoxy] -4-pyrimidinyl] aminosulfonamide

Depropylmethacetin

D4-N-Despropyl Macitentan

1103522-45-7

110-65-7

C16H14Br2N6O4S

APIS

API