ACT-132577

ChemicalBook > CAS DataBase List > ACT-132577

Product Name: ACT-132577
CAS No.: 1103522-45-7
Chemical Name: ACT-132577
Synonyms: ACT-132577;Aprocitentan;Despropyl Macitentan;Macitentan ACT-132577;N-Despropyl Macitentan;Macitentan Impurity 07;Macitentan ACT-132577-D4;Macitentan N-Despropyl Impurity;Despropyl Macitentan (COLD SHIPMENT REQUIRED);APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN
CBNumber: CB12685914
Molecular Formula: C16H14Br2N6O4S
Formula Weight: 546.19
MOL File: 1103522-45-7.mol

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ACT-132577 Property

Melting point:: 139-141°C
Boiling point:: 705.0±70.0 °C(Predicted)
Density: 1.841±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 13.56±0.60(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 5mg
Price: $305
Updated: 2021/12/16

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 10mg
Price: $580
Updated: 2021/12/16

TRC

Product number: D297305
Product name: N-DespropylMacitentan
Packaging: 50mg
Price: $1635
Updated: 2021/12/16

ChemScene

Product number: CS-2687
Product name: Aprocitentan
Purity: 98.13%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-2687
Product name: Aprocitentan
Purity: 98.13%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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ACT-132577 Chemical Properties,Usage,Production

Uses

N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

Definition

ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

ACT-132577 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ACT-132577 manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: Aprocitentan 1103522-45-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000
Release date: 2024-05-28

1103522-45-7, ACT-132577Related Search:

N-Despropyl Macitentan

Aprocitentan

5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE

ACT-132577

N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide

APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN

Despropyl Macitentan

Macitentan N-Despropyl Impurity

Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-

N-[5-(4-bromophenyl)-6-[2-(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl

Macitentan ACT-132577

5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine

Macitentan ACT-132577-D4

N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]aminosulfonamide

5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]sulfamide

Macitentan Impurity 07

Despropyl Macitentan (COLD SHIPMENT REQUIRED)

N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide

1103522-45-7

C16H14Br2N6O4S

APIS

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