ChemicalBook > CAS DataBase List > ACT-132577
ACT-132577
- Product Name
- ACT-132577
- CAS No.
- 1103522-45-7
- Chemical Name
- ACT-132577
- Synonyms
- ACT-132577;Aprocitentan;Despropyl Macitentan;Macitentan ACT-132577;N-Despropyl Macitentan;Macitentan Impurity 07;Macitentan ACT-132577-D4;Macitentan N-Despropyl Impurity;Despropyl Macitentan (COLD SHIPMENT REQUIRED);APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN
- CBNumber
- CB12685914
- Molecular Formula
- C16H14Br2N6O4S
- Formula Weight
- 546.19
- MOL File
- 1103522-45-7.mol
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ACT-132577 Property
- Melting point:
- 139-141°C
- Boiling point:
- 705.0±70.0 °C(Predicted)
- Density
- 1.841±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 13.56±0.60(Predicted)
- color
- White to Off-White
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N-Bromosuccinimide Price
TRC
- Product number
- D297305
- Product name
- N-DespropylMacitentan
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
TRC
- Product number
- D297305
- Product name
- N-DespropylMacitentan
- Packaging
- 5mg
- Price
- $305
- Updated
- 2021/12/16
TRC
- Product number
- D297305
- Product name
- N-DespropylMacitentan
- Packaging
- 50mg
- Price
- $1635
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2687
- Product name
- Aprocitentan
- Purity
- 98.13%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2687
- Product name
- Aprocitentan
- Purity
- 98.13%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
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ACT-132577 Chemical Properties,Usage,Production
Uses
N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
Definition
ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.
ACT-132577 Preparation Products And Raw materials
Raw materials
Preparation Products
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ACT-132577 Suppliers
- Tel
- 0512-63001269 15720870325
- sales2@biosyntech-suzhou.com
- Country
- China
- ProdList
- 55
- Advantage
- 58
- Tel
- 0551-68933033 13956024211
- Fax
- 0551-68935833
- trchem@163.com
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- China
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- 87
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- 58
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
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- China
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- 480
- Advantage
- 55
- Tel
- 18954159893
- demi@pharmachemm.com
- Country
- China
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- 58
- Tel
- 19852800611
- zhangqian@esteemed.cn
- Country
- China
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- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
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- Tel
- 0556-5032306 18917961636
- Fax
- +86-556-5032307
- wtx@bayeebio.com
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- China
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- Tel
- 17702719238 17702719238
- sales@sun-shinechem.com
- Country
- China
- ProdList
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- Tel
- 13327700685
- Fax
- +86-25-58744115
- sales@vcarepharmatech.com
- Country
- China
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- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14055
- Advantage
- 65
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View Lastest Price from ACT-132577 manufacturers
Jinan Jianfeng Chemical Co., Ltd
- Product
- Aprocitentan 1103522-45-7
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000
- Release date
- 2024-05-28