c-GpAp

Product Name: c-GpAp
CAS No.: 849214-04-6
Chemical Name: c-GpAp
Synonyms: cGAMP;c-GpAp;di-GAMP;di-cGAMP;3'3'-cGAMP;Cyclic GMP-AMP;cGAMP free acid;cGAMP ammonium salt;cGAMP 3',3'-cGAMP;cGAMP (Cyclic GMP-AMP
CBNumber: CB12695700
Molecular Formula: C20H24N10O13P2
Formula Weight: 674.41
MOL File: 849214-04-6.mol

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c-GpAp Property

Boiling point:: 1159.9±75.0 °C(Predicted)
Density: 2.61±0.1 g/cm3(Predicted)
storage temp.: -20°C
form: powder
pka: 0.96±0.70(Predicted)
color: white to beige
Water Solubility: Water : 20 mg/mL (29.66 mM)
InChIKey: RFCBNSCSPXMEBK-VBLLSAMJNA-N
SMILES: c1nc(N)c2nc[n]([C@H]3[C@@H](O)[C@@H]4OP(O)(=O)OC[C@@H]5O[C@@H]([n]6cnc7C(=O)N=C(N)Nc67)[C@@H](O)[C@@H]5OP(O)(=O)OC[C@@H]4O3)c2n1 |&1:8,9,11,18,20,32,34,41,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1232
Product name: cGAMP sodium salt
Purity: ≥98% (HPLC)
Packaging: 0.5 μmol
Price: $221.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1232
Product name: cGAMP sodium salt
Purity: ≥98% (HPLC)
Packaging: .5UMO
Price: $211
Updated: 2023/06/20

TRC

Product number: G110500
Product name: c-GpAp
Packaging: 10mg
Price: $13390
Updated: 2021/12/16

ChemScene

Product number: CS-3892
Product name: cGAMP
Purity: 99.22%
Packaging: 10mg
Price: $2150
Updated: 2021/12/16

ChemScene

Product number: CS-3892
Product name: cGAMP
Purity: 99.22%
Packaging: 25mg
Price: $3750
Updated: 2021/12/16

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c-GpAp Chemical Properties,Usage,Production

Uses

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Uses

c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.

Definition

ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).

Biochem/physiol Actions

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

in vivo

cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice^[2].

Animal Model:	Female C57BL/6 (H-2b) mice 6–8 weeks old^[2]
Dosage:	5 μg
Administration:	Nostril mucosal adjuvant
Result:	Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

storage

+4°C

c-GpAp Preparation Products And Raw materials

Raw materials

Preparation Products

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c-GpAp Suppliers

Canada 1 China 101 India 2 United Kingdom 1 United States 8 Global 113

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849214-04-6, c-GpApRelated Search:

c-GpAp

di-GAMP

di-cGAMP

cGAMP (Cyclic GMP-AMP

3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide

3',3'-Cyclic guanosine monophosphate-adenosine monophosphate

cGAMP

3'3'-cGAMP

RFCBNSCSPXMEBK-XRIIRFCZSA-N

c-(ApGp) / 3'3'-cGAMP

Cyclic GMP-AMP

cGAMP ammonium salt

cGAMP free acid

cGAMP 3',3'-cGAMP

2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one

cGAMP disodium salt, STING agonist

3|3|-cGAMP (3',3'-Cyclic GMP-AMP

849214-04-6

C20H22N10O13P22Na

Nucleotides, Bases & Related Reagents, Derivatives