ChemicalBook > CAS DataBase List > c-GpAp

c-GpAp

Product Name
c-GpAp
CAS No.
849214-04-6
Chemical Name
c-GpAp
Synonyms
cGAMP;c-GpAp;di-GAMP;di-cGAMP;3'3'-cGAMP;Cyclic GMP-AMP;cGAMP free acid;cGAMP ammonium salt;cGAMP 3',3'-cGAMP;cGAMP (Cyclic GMP-AMP
CBNumber
CB12695700
Molecular Formula
C20H24N10O13P2
Formula Weight
674.41
MOL File
849214-04-6.mol
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c-GpAp Property

Boiling point:
1159.9±75.0 °C(Predicted)
Density 
2.61±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
powder
pka
0.96±0.70(Predicted)
color 
white to beige
Water Solubility 
Water : 20 mg/mL (29.66 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1232
Product name
cGAMP sodium salt
Purity
≥98% (HPLC)
Packaging
.5UMO
Price
$211
Updated
2023/06/20
TRC
Product number
G110500
Product name
c-GpAp
Packaging
10mg
Price
$13390
Updated
2021/12/16
ChemScene
Product number
CS-3892
Product name
cGAMP
Purity
99.22%
Packaging
10mg
Price
$2150
Updated
2021/12/16
ChemScene
Product number
CS-3892
Product name
cGAMP
Purity
99.22%
Packaging
25mg
Price
$3750
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC137624
Product name
3',3'-Cyclic guanosine monophosphate-adenosine monophosphate
Packaging
500ug
Price
$300
Updated
2021/12/16
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c-GpAp Chemical Properties,Usage,Production

Uses

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Uses

c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.

Definition

ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).

Biochem/physiol Actions

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

storage

+4°C

c-GpAp Preparation Products And Raw materials

Raw materials

Preparation Products

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c-GpAp Suppliers

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849214-04-6, c-GpApRelated Search:


  • c-GpAp
  • di-GAMP
  • di-cGAMP
  • cGAMP (Cyclic GMP-AMP
  • 3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide
  • 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate
  • cGAMP
  • 3'3'-cGAMP
  • RFCBNSCSPXMEBK-XRIIRFCZSA-N
  • c-(ApGp) / 3'3'-cGAMP
  • Cyclic GMP-AMP
  • cGAMP ammonium salt
  • cGAMP free acid
  • cGAMP 3',3'-cGAMP
  • 2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one
  • cGAMP disodium salt, STING agonist
  • 849214-04-6
  • C20H22N10O13P22Na
  • Nucleotides, Bases & Related Reagents, Derivatives