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Omaveloxolone

Product Name
Omaveloxolone
CAS No.
1474034-05-3
Chemical Name
Omaveloxolone
Synonyms
CS-1306;RTA-408;Omaveloxolone;Nrf1-activator-1;RTA-408;RTA 408;RTA408;RTA-408(Omaveloxolone);Omaveloxolone (RTA-408);Clopidogrel Impurity 115;Omaveloxolone, 10 mM in DMSO;Omaveloxolone (RTA-408) ，S7672
CBNumber
CB12705090
Molecular Formula
C33H44F2N2O3
Formula Weight
554.71
MOL File
1474034-05-3.mol
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Omaveloxolone Property

Boiling point:
662.0±55.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥55.5 mg/mL in DMSO; insoluble in H2O; ≥25.05 mg/mL in EtOH
form 
Powder
pka
13.71±0.70(Predicted)
color 
White to off-white
InChIKey
RJCWBNBKOKFWNY-IDPLTSGASA-N
SMILES
C(N[C@]12[C@@]([C@]3(C(=O)C=C4[C@]5(C)[C@](CC[C@]4([C@@]3(CC1)C)C)([H])[C@](C)(C)C(=O)C(C#N)=C5)[H])([H])C[C@@](C)(C)CC2)(=O)C(F)(F)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H332Harmful if inhaled

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P312IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17854
Product name
RTA 408
Purity
≥98%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
17854
Product name
RTA 408
Purity
≥98%
Packaging
5mg
Price
$250
Updated
2024/03/01
Cayman Chemical
Product number
17854
Product name
RTA 408
Purity
≥98%
Packaging
10mg
Price
$468
Updated
2024/03/01
Cayman Chemical
Product number
17854
Product name
RTA 408
Purity
≥98%
Packaging
25mg
Price
$1019
Updated
2024/03/01
TRC
Product number
R700990
Product name
RTA408
Packaging
25mg
Price
$1155
Updated
2021/12/16
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Omaveloxolone Chemical Properties,Usage,Production

Uses

Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.

Biological Activity

omaveloxolone (rta-408) is a novel synthetic triterpenoid that binds to kelch-like ech-associated protein 1 (keap1) and attenuate nuclear factor erythroid 2-related factor 2 (nrf2) degradation [1].keap1 is involved in proteasomal degradation of nrf2, thereby maintaining low basal levels of nrf2. binding to keap1 and blocking its ability to promote nrf2 degradation increase newly synthesized nrf2 accumulated in the nucleus where nrf2 increases the expression of antioxidant genes and decreases the expression of pro-inflammatory genes [1].in interferon-γ-stimulated raw 264.7 macrophage cells, low concentrations (≤ 25 nm) of rta-408 activated nrf2 and lowered nitric oxide and pro-inflammatory cytokine levels. at higher concentrations, rta-408 inhibited tumor cell growth, with gi50 of 260 ± 74 nm. meanwhile, rta-408 increased caspase activity in tumor cell lines, but not in normal primary human cells.in mice with radiation-induced dermatitis, topical application of rta-408 (0.01%, 0.1% and 1.0%, q.d.) resulted in dose-dependent improvements in the appearance of skin, with 1.0% rta-408 markedly reducing epidermal and collagen thickening, preventing dermal necrosis, and completely alleviating skin ulcers [2].[1]. probst b l, trevino i, mccauley l, et al. rta 408, a novel synthetic triterpenoid with broad anticancer and anti-inflammatory activity. plos one, 2015, 10(4): e0122942.[2]. reisman s a, lee c y, meyer c j, et al. topical application of the synthetic triterpenoid rta 408 protects mice from radiation-induced dermatitis. radiation research, 2014, 181(5): 512-520.

in vivo

To determine whether Omaveloxolone (RTA-408) is an effective mitigator of hematopoietic acute radiation syndrome after bone marrow-lethal doses of total-body irradiation (TBI), mice are administered 3 daily injections of 17.5 mg/kg Omaveloxolone beginning 24 h after TBI. Teatment with Omaveloxolone results in the 35 day survival of 100% of 7 Gy (LD40/35) TBI mice (P<0.05) and 60% of 7.5 Gy (LD100/13) TBI mice (P<0.0001)[2].

Omaveloxolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Omaveloxolone Suppliers

China 103 India 1 The Netherlands 1 United States 11 Global 116
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Shanghai Botanicure Co.,Ltd
Tel
18616900167
Email
hr@botanicure.com
Country
China
ProdList
68
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
Country
China
ProdList
436
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
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View Lastest Price from Omaveloxolone manufacturers

Career Henan Chemical Co
Product
RTA-408 1474034-05-3
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

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