3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER
Uses- Product Name
- 3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 197506-83-5
- Chemical Name
- 3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- RARECHEM AH BS 0103;Methyl 3-forMylindole-5-c...;METHYL 3-FORMYLINDOLE-5-CARBOXYLATE;METHYL 3-FORMYL-1H-INDOLE-5-CARBOXYLATE;3-FORMYLINDOLE-5-CARBOXYLIC ACID METHYL ESTER;INDOLE-3-ALDEHYDE-5-CARBOXYLIC ACID METHYL ESTER;3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER;1H-Indole-5-carboxylic acid, 3-formyl-, methyl ester;INDOLE-3-CARBOXALDEHYDE-5-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB1270677
- Molecular Formula
- C11H9NO3
- Formula Weight
- 203.19
- MOL File
- 197506-83-5.mol
3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 404.4±25.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 14.59±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 197506-83-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M321515
- Product name
- Methyl3-Formyl-1H-indole-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B471
- Product name
- Methyl-3-Formylindole-5-carboxylate
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 115390
- Product name
- 3-Formylindole-5-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $519
- Updated
- 2021/12/16
- Product number
- CHM0023536
- Product name
- 3-FORMYLINDOLE-5-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $910.76
- Updated
- 2021/12/16
- Product number
- CHM0023536
- Product name
- 3-FORMYLINDOLE-5-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1337.31
- Updated
- 2021/12/16
3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
3-Aldehydeindole-5-carboxylic acid methyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical and chemical intermediate.
Synthesis
1011-65-0
68-12-2
197506-83-5
Methyl 1H-indole-5-carboxylate (11 g, 62.3 mmol) was dissolved in 100 mL of N,N-dimethylformamide (DMF) at 0 °C and phosphorus oxychloride (POCl3, 7.9 mL, 84.8 mmol) was added slowly. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of 350 mL of water and the mixture was heated to reflux for 15 minutes to form a brown suspension. After cooling to room temperature, a large amount of precipitate was observed to be generated. Subsequently, an additional 300 mL of water was added and stirring was continued for 10 minutes. The solid product was collected by filtration, washed sequentially with water and hexane, and finally dried under vacuum at 60 °C overnight to afford methyl 3-formylindole-5-carboxylate (12.7 g, 99.5% yield) as a pale pink solid.
References
[1] Patent: US2006/276496, 2006, A1. Location in patent: Page/Page column 62; 63
[2] Patent: WO2017/136395, 2017, A1. Location in patent: Page/Page column 263
[3] Chemistry - A European Journal, 2016, vol. 22, # 2, p. 716 - 723
[4] Patent: US2012/309757, 2012, A1. Location in patent: Page/Page column 170
[5] Journal of Antibiotics, 2017, vol. 70, # 7, p. 832 - 844
3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER 197506-83-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08