5-METHYLINDOLE-3-CARBOXALDEHYDE
- Product Name
- 5-METHYLINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 52562-50-2
- Chemical Name
- 5-METHYLINDOLE-3-CARBOXALDEHYDE
- Synonyms
- NSC 88872;AKOS JY2082657;CBI-BB ZERO/005313;5-METHYLINDOLE-3-ALDEHYDE;5-METHYLINDOLE-3-CARBALDEHYDE;5-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHYLINDOLE-3-CARBOXYALDEHYDE;5-METHYL-1H-INDOLE-3-CARBALDEHYDE;5-Methyl-1H-indole-3-carboxaldehyde;5-Methylindole-3-carboxaldehyde 98%
- CBNumber
- CB8438360
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 52562-50-2.mol
5-METHYLINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 148-151 °C(lit.)
- Boiling point:
- 348.2±22.0 °C(Predicted)
- Density
- 1.226±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 15.68±0.30(Predicted)
- Appearance
- Off-white to pink Solid
- CAS DataBase Reference
- 52562-50-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 134139
- Product name
- 5-Methylindole-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $218
- Updated
- 2023/06/20
- Product number
- 134139
- Product name
- 5-Methylindole-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $509
- Updated
- 2023/06/20
- Product number
- M320893
- Product name
- 5-Methyl-1H-indole-3-carbaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR1664
- Product name
- 5-Methylindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H15-1-T6
- Product name
- 5-Methylindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
5-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
5-Methyl-1H-indole-3-carbaldehyde (cas# 52562-50-2) is a useful reagent for regio- and enantioselective preparation of N-alkylated indole- and pyrrole-3-carbaldehydes.
Uses
5-Methylindole-3-carboxaldehyde was used in the synthesis of novel flexible tripodal ligand derived from 3-methylindole and its mononuclear Zn(II),Cu(II), Ni(II), Hg(II) and Pd(II) complexes.
Synthesis
614-96-0
68-12-2
52562-50-2
GENERAL STEPS: Oxalyl chloride (0.3 mL) was slowly added dropwise to cooled (ice bath) N,N-dimethylformamide (DMF, 3 mL) under stirring conditions. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, a solution of 5-methylindole (4 mmol) dissolved in DMF (1.5 mL) was added slowly dropwise to the above reaction mixture. The resulting mixture was stirred and reacted at room temperature for 5 hours. Upon completion of the reaction, 2N sodium hydroxide solution (2 mL) was added and the mixture was heated to 100 °C and maintained for 10 min. The reaction solution was cooled and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of ethyl acetate/petroleum ether (3:1, v/v) to finally obtain the purified 5-methyl-1H-indole-3-carbaldehyde.
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[2] Patent: EP1932833, 2008, A1. Location in patent: Page/Page column 11; 12
[3] Chemistry - A European Journal, 2016, vol. 22, # 2, p. 716 - 723
[4] Marine Drugs, 2014, vol. 12, # 4, p. 1757 - 1772
[5] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 70 - 81
5-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers
- Product
- 5-Methyl-1H-indole-3-carbaldehyde 52562-50-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 5-METHYLINDOLE-3-CARBOXALDEHYDE 52562-50-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2018-12-17