ChemicalBook > CAS DataBase List > 5-METHYLINDOLE-3-CARBOXALDEHYDE

5-METHYLINDOLE-3-CARBOXALDEHYDE

Product Name
5-METHYLINDOLE-3-CARBOXALDEHYDE
CAS No.
52562-50-2
Chemical Name
5-METHYLINDOLE-3-CARBOXALDEHYDE
Synonyms
NSC 88872;AKOS JY2082657;CBI-BB ZERO/005313;5-METHYLINDOLE-3-ALDEHYDE;5-METHYLINDOLE-3-CARBALDEHYDE;5-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHYLINDOLE-3-CARBOXYALDEHYDE;5-METHYL-1H-INDOLE-3-CARBALDEHYDE;5-Methyl-1H-indole-3-carboxaldehyde;5-Methylindole-3-carboxaldehyde 98%
CBNumber
CB8438360
Molecular Formula
C10H9NO
Formula Weight
159.18
MOL File
52562-50-2.mol
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5-METHYLINDOLE-3-CARBOXALDEHYDE Property

Melting point:
148-151 °C(lit.)
Boiling point:
348.2±22.0 °C(Predicted)
Density 
1.226±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
15.68±0.30(Predicted)
Appearance
Off-white to pink Solid
CAS DataBase Reference
52562-50-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
134139
Product name
5-Methylindole-3-carboxaldehyde
Purity
97%
Packaging
1g
Price
$218
Updated
2023/06/20
Sigma-Aldrich
Product number
134139
Product name
5-Methylindole-3-carboxaldehyde
Purity
97%
Packaging
5g
Price
$509
Updated
2023/06/20
TRC
Product number
M320893
Product name
5-Methyl-1H-indole-3-carbaldehyde
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR1664
Product name
5-Methylindole-3-carboxaldehyde
Purity
98%
Packaging
250mg
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-T6
Product name
5-Methylindole-3-carboxaldehyde
Purity
98%
Packaging
250mg
Price
$55
Updated
2021/12/16
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5-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

5-Methyl-1H-indole-3-carbaldehyde (cas# 52562-50-2) is a useful reagent for regio- and enantioselective preparation of N-alkylated indole- and pyrrole-3-carbaldehydes.

Uses

5-Methylindole-3-carboxaldehyde was used in the synthesis of novel flexible tripodal ligand derived from 3-methylindole and its mononuclear Zn(II),Cu(II), Ni(II), Hg(II) and Pd(II) complexes.

Synthesis

614-96-0

68-12-2

52562-50-2

GENERAL STEPS: Oxalyl chloride (0.3 mL) was slowly added dropwise to cooled (ice bath) N,N-dimethylformamide (DMF, 3 mL) under stirring conditions. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, a solution of 5-methylindole (4 mmol) dissolved in DMF (1.5 mL) was added slowly dropwise to the above reaction mixture. The resulting mixture was stirred and reacted at room temperature for 5 hours. Upon completion of the reaction, 2N sodium hydroxide solution (2 mL) was added and the mixture was heated to 100 °C and maintained for 10 min. The reaction solution was cooled and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of ethyl acetate/petroleum ether (3:1, v/v) to finally obtain the purified 5-methyl-1H-indole-3-carbaldehyde.

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[2] Patent: EP1932833, 2008, A1. Location in patent: Page/Page column 11; 12
[3] Chemistry - A European Journal, 2016, vol. 22, # 2, p. 716 - 723
[4] Marine Drugs, 2014, vol. 12, # 4, p. 1757 - 1772
[5] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 70 - 81

5-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-Methyl-1H-indole-3-carbaldehyde 52562-50-2
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
5-METHYLINDOLE-3-CARBOXALDEHYDE 52562-50-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2018-12-17

52562-50-2, 5-METHYLINDOLE-3-CARBOXALDEHYDERelated Search:

6-METHYLINDOLE-3-CARBOXALDEHYDE,6-Methylindole-3-carboxaldehyde,98% 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER 3-FORMYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER 5-METHYLINDOLE-3-CARBOXALDEHYDE 2-METHYLINDOLE-3-CARBOXALDEHYDE,2-Methylindole-3-carboxaldehyde, 97+% 1-METHYLINDOLE-3-CARBOXALDEHYDE,1-Methylindole-3-carboxaldehyde, 98+%,1-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC) 7-METHYLINDOLE-3-CARBOXALDEHYDE,7-Methylindole-3-carboxaldehyde 98%,7-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC) 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 5-Methylindole Indole-3-carboxaldehyde 2,5-DI-TERT-BUTYL-1H-INDOLE-3-CARBALDEHYDE 5-CYANOINDOLE-3-CARBOXALDEHYDE INDOLE-3,5-DIALDEHYDE 5-TERT-BUTYL-2-(2-METHYLPHENYL)-1H-INDOLE-3-CARBALDEHYDE 3-FORMYL-5-METHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 1-METHYLINDOLE-2-CARBOXALDEHYDE 97 5-FLUORO-1-METHYLINDOLE-3-CARBOXALDEHYDE 5-Methoxy-4-methylindole-3-carboxaldehyde

  • AKOS JY2082657
  • 5-METHYLINDOLE-3-ALDEHYDE
  • 5-METHYLINDOLE-3-CARBALDEHYDE
  • 5-METHYLINDOLE-3-CARBOXALDEHYDE
  • 5-METHYLINDOLE-3-CARBOXYALDEHYDE
  • CBI-BB ZERO/005313
  • 5-METHYL-1H-INDOLE-3-CARBALDEHYDE
  • 1H-Indole-3-carboxaldehyde, 5-methyl- (9CI)
  • 5-Methylindole-3-carboxaldehyde 98%
  • 5-Methyl-1H-indole-3-carboxaldehyde
  • 5-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC)
  • 5-METHYLINDOLE-3-CARBOXALDEHYDE(5MeIAld)
  • NSC 88872
  • 1H-Indole-3-carboxaldehyde, 5-methyl-
  • 52562-50-2
  • Indoles
  • Heterocyclic Building Blocks
  • Building Blocks
  • ALDEHYDE
  • Indoles and derivatives
  • Indole
  • Heterocyclic Compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • Indoles