5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
- Product Name
- 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 39974-94-2
- Chemical Name
- 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE;AKOS JY2082772;3-Formyl-5-methoxy-1-methylindole;3-Formyl-5-methoxy-1-methyl-1H-indole;5-methoxy-1-methylindole-3-carbaldehyde;5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD;5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
- CBNumber
- CB0343873
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 39974-94-2.mol
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 133-136°C
- Boiling point:
- 357.9±22.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Brown
- Water Solubility
- It is insoluble in water.
- Sensitive
- Air Sensitive
- BRN
- 1528827
- CAS DataBase Reference
- 39974-94-2
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M223883
- Product name
- 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H15-1-41
- Product name
- 5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 038104
- Product name
- 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 4H15-1-41
- Product name
- 5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
- Packaging
- 5G
- Price
- $340
- Updated
- 2021/12/16
- Product number
- CHM0027238
- Product name
- 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $683.53
- Updated
- 2021/12/16
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
5-Methoxy-1-methylindole-3-carboxaldehyde is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
10601-19-1
74-88-4
39974-94-2
1. 5-methoxyindole-3-carboxaldehyde (300 mg, 1.71 mmol) was added to a stirring solution of sodium hydride suspension (82 mg, 2.05 mmol, 60% dispersed in mineral oil) in DMF (8 mL) in batches under argon protection, a process which needed to be completed within 5 minutes. 2. The reaction mixture was continued to be stirred for 30 minutes, followed by the addition of iodomethane (0.13 mL, 2.05 mmol) and continued stirring for 1 hour. 3. Upon completion of the reaction, 10% sodium bicarbonate solution (40 mL) was added and the mixture was extracted with ethyl acetate (4×). 4. The organic layers were combined, washed sequentially with 10% sodium bicarbonate solution (2×) and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated. 5. The crude product was purified by column chromatography (eluent: 50:50 ethyl acetate/hexane) to afford 5-methoxy-1-methylindole-3-carbaldehyde (320 mg, 99%) as a light yellow solid. Rf = 0.35 (50:50 ethyl acetate/hexane); melting point = 130-132°C (literature value: 132-133°C). 1H NMR (CDCl3): δ 9.95 (s, 1H), 7.79 (d, 1H, J = 2.4 Hz), 7.62 (s, 1H), 7.25 (d, 1H, J = 8.8 Hz), 6.96 (dd, 1H, J = 2.4 and 8.9 Hz), 3.90 (s, 3H), 3.85 (s, 3H).
References
[1] Tetrahedron, 2005, vol. 61, # 7, p. 1793 - 1801
[2] Organic Letters, 2013, vol. 15, # 11, p. 2636 - 2639
[3] Patent: US2003/8850, 2003, A1
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6261 - 6276
[5] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 731 - 745
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers
- Product
- 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 39974-94-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100JKG
- Release date
- 2020-01-14