ChemicalBook > CAS DataBase List > (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- Product Name
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- CAS No.
- 608141-43-1
- Chemical Name
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- Synonyms
- Apremilast Impurity 62;RSSYY(Lurasidone Hydrochloride)-15;(2S)-2-acetamido-4-methylpentanoate;Apremilast Impurity 4 N-Acetyl-L-Leucine Salt;Apremilast Impurity 2 N-Acetyl-L-Leucine Salt;Apremilast Impurity 21 N-Acetyl-L-Leucine Salt;Apremilast Impurity 35 N-acetyl-L-leucine Salt;Apremilast Impurity 55(N-Acetyl-L-leucine Salt);(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
- CBNumber
- CB12707852
- Molecular Formula
- C20H34N2O7S
- Formula Weight
- 446.56
- MOL File
- 608141-43-1.mol
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(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- CAS DataBase Reference
- 608141-43-1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- E898128
- Product name
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-Acetyl-L-leucineSalt
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M2810
- Product name
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt
- Purity
- 99.99%
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M2810
- Product name
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt
- Purity
- 99.99%
- Packaging
- 100g
- Price
- $375
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS93594
- Product name
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-leucine Salt
- Purity
- 95+% ee
- Packaging
- 25g
- Price
- $443
- Updated
- 2021/12/16
Chemenu
- Product number
- CM186592
- Product name
- (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amineacetyl-L-leucinate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
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(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Chemical Properties,Usage,Production
Synthesis
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:
A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt manufacturers
Hangzhou ICH Biofarm Co., Ltd
- Product
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt 608141-43-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ≥1kg
- Release date
- 2023-07-18
Career Henan Chemical Co
- Product
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt 608141-43-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-31
608141-43-1, (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine saltRelated Search:
Apremilast Impurity 9
Apremilast Impurity 2
APST-ZA
(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
3-acetamidophthalic acid
Apremilast Impurity E
Apremilast Impurity 1
Apremilast Impurity 13
Apremilast Impurity 8
Apremilast Impurity 1/2
Apremilast
ApreMilast-d5
Apremilast impurity 15
Apremilast Impurity F
Apremilast Impurity C
[[p-(2-methoxyethyl)phenoxy]methyl]oxirane
Apremilast Impurity 10