ChemicalBook > CAS DataBase List > (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt

Product Name
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
CAS No.
608141-43-1
Chemical Name
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
Synonyms
Apremilast Impurity 62;RSSYY(Lurasidone Hydrochloride)-15;(2S)-2-acetamido-4-methylpentanoate;Apremilast Impurity 4 N-Acetyl-L-Leucine Salt;Apremilast Impurity 2 N-Acetyl-L-Leucine Salt;Apremilast Impurity 21 N-Acetyl-L-Leucine Salt;Apremilast Impurity 35 N-acetyl-L-leucine Salt;Apremilast Impurity 55(N-Acetyl-L-leucine Salt);(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
CBNumber
CB12707852
Molecular Formula
C20H34N2O7S
Formula Weight
446.56
MOL File
608141-43-1.mol
More
Less

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
CAS DataBase Reference
608141-43-1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
E898128
Product name
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-Acetyl-L-leucineSalt
Packaging
500mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-M2810
Product name
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt
Purity
99.99%
Packaging
10g
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-M2810
Product name
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt
Purity
99.99%
Packaging
100g
Price
$375
Updated
2021/12/16
Activate Scientific
Product number
AS93594
Product name
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-leucine Salt
Purity
95+% ee
Packaging
25g
Price
$443
Updated
2021/12/16
Chemenu
Product number
CM186592
Product name
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amineacetyl-L-leucinate
Purity
95+%
Packaging
10g
Price
$130
Updated
2021/12/16
More
Less

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Chemical Properties,Usage,Production

Synthesis

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:
A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Suppliers

China 172 India 11 United Kingdom 1 United States 3 Global 187
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Zhongshan Haihong Medicine Co. Ltd
Tel
0760-86925768 18824993998
Fax
0760-86925770
Email
seas168@126.com
Country
China
ProdList
60
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Zhuhai Yourun Co., Ltd.
Tel
0756-6811852 13923369215
Fax
0756-6811857
Email
zhyrpharm_sales03@126.com
Country
China
ProdList
287
Advantage
55
Hangzhou Bright Pharma Biotechnology Co., Ltd.
Tel
0571-85775770 13575490453
Email
info@brightpharmabio.com
Country
China
ProdList
33
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Enantiotech Corporation Ltd
Tel
760-85282375 13212762451
Email
marketing@enantiotech.net
Country
China
ProdList
153
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
978
Advantage
62
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
More
Less

View Lastest Price from (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt manufacturers

Hangzhou ICH Biofarm Co., Ltd
Product
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt 608141-43-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
≥1kg
Release date
2023-07-18
Career Henan Chemical Co
Product
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt 608141-43-1
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-07-31

608141-43-1, (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine saltRelated Search:

Apremilast Impurity 9 Apremilast Impurity 2 APST-ZA (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide (S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide 3-acetamidophthalic acid Apremilast Impurity E Apremilast Impurity 1 Apremilast Impurity 13 Apremilast Impurity 8 Apremilast Impurity 1/2 Apremilast ApreMilast-d5 Apremilast impurity 15 Apremilast Impurity F Apremilast Impurity C [[p-(2-methoxyethyl)phenoxy]methyl]oxirane Apremilast Impurity 10

  • (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-leucine Salt
  • (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
  • N-Acetyl-L-leucine compound with (alphaS)-3-ethoxy-4-methoxy-alpha-[(methylsulfonyl)methyl]benzenemethanamine
  • (2S)-2-acetamido-4-methylpentanoate
  • [(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
  • (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate
  • (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethylamine N-acetyl L-leucine salt
  • (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate
  • L-Leucine, N-acetyl-, compd. with(aS)-3-ethoxy-4-methoxy-a-[(methylsulfonyl)methyl]benzenemethanamine (1:1)
  • Apremilast Impurity 62
  • Apremilast Impurity 55(N-Acetyl-L-leucine Salt)
  • (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...
  • RSSYY(Lurasidone Hydrochloride)-15
  • (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methyl sulfonyl)ethanamine 2-(acetamide methyl)-3- methylbutanoate
  • (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucinate
  • Apremilast Impurity 4 N-Acetyl-L-Leucine Salt
  • Apremilast Impurity 21 N-Acetyl-L-Leucine Salt
  • Apremilast Impurity 2 N-Acetyl-L-Leucine Salt
  • Apremilast Impurity 35 N-acetyl-L-leucine Salt
  • 608141-43-1
  • 608141-43-2
  • C20H34N2O7S
  • C12H19NO4SC8H15NO3