ChemicalBook > CAS DataBase List > N-(4-Mesitylthiazol-2-yl)benzaMide

N-(4-Mesitylthiazol-2-yl)benzaMide

Product Name: N-(4-Mesitylthiazol-2-yl)benzaMide
CAS No.: 1001753-24-7
Chemical Name: N-(4-Mesitylthiazol-2-yl)benzaMide
Synonyms: INH6;INH-6; INH6;INH6, 10 mM in DMSO;N-(4-Mesitylthiazol-2-yl)benzaMide;Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6;Apoptosis,Inhibitor,INH 6,INH6,INH-6,inhibit;N-(4-Mesitylthiazol-2-yl)benzaMide USP/EP/BP;N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide;N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-
CBNumber: CB12707933
Molecular Formula: C19H18N2OS
Formula Weight: 322.42
MOL File: 1001753-24-7.mol

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N-(4-Mesitylthiazol-2-yl)benzaMide Property

Melting point:: 192-193 °C
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic
form: Powder
pka: 7.07±0.70(Predicted)
color: White to off-white
CAS DataBase Reference: 1001753-24-7

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 373271
Product name: Hec1/Nek2MitoticPathwayInhibitorII,INH6-CAS1001753-24-7-Calbiochem
Purity: TheHec1/Nek2MitoticPathwayInhibitorII,INH6,alsoreferencedunderCAS1001
Packaging: 10mg
Price: $167
Updated: 2023/06/20

Cayman Chemical

Product number: 21772
Product name: INH6
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21772
Product name: INH6
Purity: ≥98%
Packaging: 5mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 21772
Product name: INH6
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 21772
Product name: INH6
Purity: ≥98%
Packaging: 25mg
Price: $249
Updated: 2024/03/01

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N-(4-Mesitylthiazol-2-yl)benzaMide Chemical Properties,Usage,Production

Uses

INH6 is a Hec1 inhibitor that targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death.

Biological Activity

inh6 is a potent inhibitor of hec1/nek2 [1].hec1 is an oncogene that involved in spindle checkpoint signaling and is overexpressed in many human cancers. nek2 is a serine/threonine-protein kinase that phosphorylates hec1, which is critical for its mitotic function and cell survival [1].inh6 is a potent hec1/nek2 inhibitor. inh6 inhibited hec1/nek2 function through protein degradation that led to chromosome mis-segregation and cell death. in mda-mb468 and mda-mb231 human breast cancer cell lines, hela human cervical cancer line and k562 human erythromyeloblastoid leukemia cell line, inh6 exhibited significantly anti-proliferation activities with ic50 values of 2.1, 1.7, 2.4 and 2.5 μm, respectively. in hela cell extract, inh6-conjugated matrix selectively co-precipitated with cellular hec1, which suggested that inh6 bound to cellular hec1. in hela cells, inh6 (6.25 μm) reduced nek2 by 50% at 8-11 h. in addition, inh6 slightly reduced hec1 over time. also, inh6 increased mitotic population with multipolar spindle configurations. in hela cells expressing the chromosome marker protein h2b-gfp, inh6 increased chromosome misalignment. in hela cells, inh6 exhibited progressive morphological changes of dying cells and induced apoptosis by 20% [1].

target

Hec1/Nek2 complex

IC 50

NEK2

References

[1]. qiu xl, li g, wu g, et al. synthesis and biological evaluation of a series of novel inhibitor of nek2/hec1 analogues. j med chem, 2009, 52(6): 1757-1767.

N-(4-Mesitylthiazol-2-yl)benzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(4-Mesitylthiazol-2-yl)benzaMide manufacturers

Career Henan Chemical Co

Product: INH6 1001753-24-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

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N-(4-Mesitylthiazol-2-yl)benzaMide

INH6

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide

N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide

INH-6; INH6

N-(4-Mesitylthiazol-2-yl)benzaMide USP/EP/BP

Apoptosis,Inhibitor,INH 6,INH6,INH-6,inhibit

Benzamide, N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-

INH6, 10 mM in DMSO

Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6

1001753-24-7

Inhibitors