ChemicalBook > CAS DataBase List > N-(4-Mesitylthiazol-2-yl)benzaMide
N-(4-Mesitylthiazol-2-yl)benzaMide
- Product Name
- N-(4-Mesitylthiazol-2-yl)benzaMide
- CAS No.
- 1001753-24-7
- Chemical Name
- N-(4-Mesitylthiazol-2-yl)benzaMide
- Synonyms
- INH6;INH-6; INH6;N-(4-Mesitylthiazol-2-yl)benzaMide;Apoptosis,Inhibitor,INH 6,INH6,INH-6,inhibit;N-(4-Mesitylthiazol-2-yl)benzaMide USP/EP/BP;N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide;N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-
- CBNumber
- CB12707933
- Molecular Formula
- C19H18N2OS
- Formula Weight
- 322.42
- MOL File
- 1001753-24-7.mol
More
Less
N-(4-Mesitylthiazol-2-yl)benzaMide Property
- Melting point:
- 192-193 °C
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic
- form
- Powder
- pka
- 7.07±0.70(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 1001753-24-7
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 373271
- Product name
- Hec1/Nek2MitoticPathwayInhibitorII,INH6-CAS1001753-24-7-Calbiochem
- Purity
- TheHec1/Nek2MitoticPathwayInhibitorII,INH6,alsoreferencedunderCAS1001
- Packaging
- 10mg
- Price
- $167
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $76
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
More
Less
N-(4-Mesitylthiazol-2-yl)benzaMide Chemical Properties,Usage,Production
Uses
INH6 is a Hec1 inhibitor that targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death.
Biological Activity
inh6 is a potent inhibitor of hec1/nek2 [1].hec1 is an oncogene that involved in spindle checkpoint signaling and is overexpressed in many human cancers. nek2 is a serine/threonine-protein kinase that phosphorylates hec1, which is critical for its mitotic function and cell survival [1].inh6 is a potent hec1/nek2 inhibitor. inh6 inhibited hec1/nek2 function through protein degradation that led to chromosome mis-segregation and cell death. in mda-mb468 and mda-mb231 human breast cancer cell lines, hela human cervical cancer line and k562 human erythromyeloblastoid leukemia cell line, inh6 exhibited significantly anti-proliferation activities with ic50 values of 2.1, 1.7, 2.4 and 2.5 μm, respectively. in hela cell extract, inh6-conjugated matrix selectively co-precipitated with cellular hec1, which suggested that inh6 bound to cellular hec1. in hela cells, inh6 (6.25 μm) reduced nek2 by 50% at 8-11 h. in addition, inh6 slightly reduced hec1 over time. also, inh6 increased mitotic population with multipolar spindle configurations. in hela cells expressing the chromosome marker protein h2b-gfp, inh6 increased chromosome misalignment. in hela cells, inh6 exhibited progressive morphological changes of dying cells and induced apoptosis by 20% [1].
target
Hec1/Nek2 complex
References
[1]. qiu xl, li g, wu g, et al. synthesis and biological evaluation of a series of novel inhibitor of nek2/hec1 analogues. j med chem, 2009, 52(6): 1757-1767.
N-(4-Mesitylthiazol-2-yl)benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
N-(4-Mesitylthiazol-2-yl)benzaMide Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5806
- Advantage
- 50
- Tel
- 021-58930698 15921516558
- Fax
- 86-021-58933679
- zhangyichao84@126.com
- Country
- China
- ProdList
- 916
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 18800159827
- youcochem@163.com
- Country
- China
- ProdList
- 161
- Advantage
- 50
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 1009
- Advantage
- 55
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4999
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 4601
- Advantage
- 55
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7267
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4983
- Advantage
- 55
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@Medchemleader.com
- Country
- China
- ProdList
- 1005
- Advantage
- 58
- Tel
- 0755-0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9355
- Advantage
- 58
- Tel
- 15981811963
- Fax
- QQ：1410472904
- 1410472904@qq.com
- Country
- China
- ProdList
- 5825
- Advantage
- 58
- Tel
- 0371-0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9882
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3251
- Advantage
- 58
- Tel
- 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 13010
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +86-0576-88813233 +86-13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 1990
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3960
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 22883
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 63313187 15358055255
- Fax
- QQ：63313187
- 63313187@qq.com
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29811
- Advantage
- 58
- Tel
- 021-61998551 13122364865
- sale1@shzysw.net
- Country
- China
- ProdList
- 9772
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 15527250409
- Fax
- QQ：2692360204
- wenhaotian12@163.com
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 3733
- Advantage
- 58
- Tel
- 18964309092 18964309092
- 2769493375@qq.com
- Country
- China
- ProdList
- 2634
- Advantage
- 58
- Tel
- 0513-68819626; 15152877458
- Fax
- 0513-68669626
- feiyubio@163.com
- Country
- China
- ProdList
- 4819
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
More
Less
View Lastest Price from N-(4-Mesitylthiazol-2-yl)benzaMide manufacturers
Career Henan Chemical Co
- Product
- INH6 1001753-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30
1001753-24-7, N-(4-Mesitylthiazol-2-yl)benzaMideRelated Search:
Acetanilide
4-Aminodiphenylamine
Vincristine sulfate
CYT997
VINBLASTINE
E 7010
Docetaxel
Epothilone B