WAY100635

Product Name: WAY100635
CAS No.: 1092679-51-0
Chemical Name: WAY100635
Synonyms: CS-998;PectDrill;WAY100635 100MG;Superthiol sirup;WAY100635 USP/EP/BP;WAY-100635 Monomaleate;WAY-100635 Maleate ，S2663;WAY-100635 Monomaleate, 10 mM in DMSO;Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1);WAY-100635 (maleate) N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate
CBNumber: CB12708132
Molecular Formula: C29H38N4O6
Formula Weight: 538.65
MOL File: 1092679-51-0.mol

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WAY100635 Property

storage temp.: Store at -20°C
solubility: ≥53.9 mg/mL in DMSO; ≥51.2 mg/mL in EtOH; ≥6.08 mg/mL in H2O with ultrasonic
form: solid
color: White to off-white
Water Solubility: Soluble to 25 mM in water

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Safety

HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: W0016
Product name: WAY-100635 Maleate
Packaging: 10MG
Price: $163
Updated: 2025/07/31

TCI Chemical

Product number: W0016
Product name: WAY-100635 Maleate
Packaging: 50MG
Price: $490
Updated: 2025/07/31

Cayman Chemical

Product number: 14599
Product name: WAY-100635 (maleate)
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 14599
Product name: WAY-100635 (maleate)
Purity: ≥95%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 14599
Product name: WAY-100635 (maleate)
Purity: ≥95%
Packaging: 50mg
Price: $515
Updated: 2024/03/01

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WAY100635 Chemical Properties,Usage,Production

Description

WAY-100635 is a potent, silent antagonist of serotonin 5-HT_1A receptors with an IC₅₀ value of 2.2 nM (K_i = 0.8 nM) for inhibiting 5-HT_1A receptors in rat hippocampal membranes. Because it displays 100-fold selectivity for 5-HT_1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT_1A receptors. However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D₄ receptors (K_d = 2.4 nM).

Uses

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist[1][2][3].

in vivo

WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat^[2].

Animal Model:	Male Sprague-Dawley rats (220-240 g)^[2]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection (Pharmacokinetic study)
Result:	Reduced total abstinence score, increased immobility time and the burying behavior was increased.

IC 50

D₄ Receptor; sPLA2: 8.87 (pIC₅₀); sPLA2: 9.71 (pA2)

storage

Desiccate at RT

References

[1] Chemel BR, et al. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl). 2006 Oct;188(2):244-51. DOI:10.1007/s00213-006-0490-4
[2] Mannucci C, et al. Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. 2012 Sep 15;19(12):1117-24. DOI:10.1016/j.phymed.2012.07.001
[3] Al Hussainy R, et al. Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinatedanalogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. J Med Chem. 2011 May 26;54(10):3480-91. DOI:10.1021/jm1009956

WAY100635 Preparation Products And Raw materials

Raw materials

Preparation Products

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WAY100635 Suppliers

China 58 India 1 Japan 1 United Kingdom 1 United States 8 Global 69

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1092679-51-0, WAY100635Related Search:

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Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1)

WAY-100635 (maleate) N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate

WAY100635 100MG

CS-998

WAY100635 USP/EP/BP

PectDrill

Superthiol sirup

WAY-100635 Monomaleate

WAY-100635 Monomaleate, 10 mM in DMSO

WAY-100635 Maleate ，S2663

1092679-51-0

Inhibitors