2,4-Dichloro-3-Methylacetophenone Property

Melting point:

38 °C

Boiling point:

147-148 °C(Press: 10 Torr)

Density 

1.260±0.06 g/cm3(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

2,4-Dichloro-3-Methylacetophenone Chemical Properties,Usage,Production

Uses

2,4-Dichloro-3-methylacetophenone is an intermediate used to synthesize 7-Chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxo-3-quinolinecarboxylic Acid (C364875) which is a medical bactericide.

Synthesis

Aluminum chloride (49.68 g, 372.60 mmol) and 2,6-dichloro toluene (50.00 g, 310.50 mmol) were added to the single-mouth flask under stir at room temperature. Then acetyl chloride (26.81 g, 341.60 mmol) is added dropwise. The reaction was heated to 40°C for 2 hours, and the reaction of the raw materials was monitored by TLC to be complete. Pour the system slowly into ice water (500mL), dilute hydrochloric acid solution(1M, 30mL) acidified, extracted with dichloromethane (150mL x 3). It was dried over anhydrous sodium sulfate and concentrated to obtain 2,4-Dichloro-3-Methylacetophenone as a colorless oil with a yield of 95%.