AGN 196996

Product Name: AGN 196996
CAS No.: 958295-17-5
Chemical Name: AGN 196996
Synonyms: CS-1210;VTP 196696;AGN 196996;Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]-
CBNumber: CB12715604
Molecular Formula: C24H20BrNO5
Formula Weight: 482.32
MOL File: 958295-17-5.mol

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AGN 196996 Property

storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31000069
Product name: AGN196996
Purity: 98+%
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Crysdot

Product number: CD31000069
Product name: AGN196996
Purity: 98+%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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AGN 196996 Chemical Properties,Usage,Production

Description

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

References

References:[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

AGN 196996 Preparation Products And Raw materials

Raw materials

Preparation Products

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AGN 196996 Suppliers

China 21 United States 8 Global 29

MedChemexpress LLC

Tel: 021-58955995
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Musechem

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Email: zijue.cai@tsbiochem.com
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Aladdin Scientific

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BOC Sciences

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958295-17-5, AGN 196996Related Search:

VTP 196696

CS-1210

AGN 196996

Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]-

958295-17-5

APIS