ChemicalBook > CAS DataBase List > D8-MMAE
D8-MMAE
- Product Name
- D8-MMAE
- CAS No.
- 2070009-72-0
- Chemical Name
- D8-MMAE
- Synonyms
- MMAE-d8;D8-MMAE;2H8]-MMAE;MMAE-d-8,MMAE d8,MMAEd8;D8-Monomethyl auristatin E
- CBNumber
- CB12715624
- Molecular Formula
- C39H59D8N5O7
- Formula Weight
- 726.027874224
- MOL File
- 2070009-72-0.mol
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D8-MMAE Property
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO : 100 mg/mL (137.74 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-3368
- Product name
- D8-MMAE
- Purity
- 99.29%
- Packaging
- 1mg
- Price
- $1320
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3368
- Product name
- D8-MMAE
- Purity
- 99.29%
- Packaging
- 5mg
- Price
- $3000
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3368
- Product name
- D8-MMAE
- Purity
- 99.29%
- Packaging
- 10mg
- Price
- $5640
- Updated
- 2021/12/16
aablocks
- Product number
- AA01EOLQ
- Product name
- D8-MMAE
- Purity
- 99%
- Packaging
- 10mg
- Price
- $6302
- Updated
- 2021/12/16
aablocks
- Product number
- AA01EOLQ
- Product name
- D8-MMAE
- Purity
- 99%
- Packaging
- 5mg
- Price
- $3369
- Updated
- 2021/12/16
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D8-MMAE Chemical Properties,Usage,Production
Biological Activity
D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE. MMAE is a tubulin inhibitor that inhibits mitosis.
in vivo
Intratumoral MMAE concentrations consistently correlates with the extent of tumor growth inhibition in tumor xenograft models. IHC analysis reveals that nonbinding control-treated tumors consist of both CD30 + and CD30 - cells, presumably because they do not kill either CD30 + or CD30 - Karpas 299 cells. Only CD30 - cells are found in cAC10-vcMMAF-treated tumors, illustrating that cAC10-vcMMAF eliminates most CD30 + cells. Interestingly, the two tumors that relapses from cAC10-vcMMAE treatment are also found to be CD30 - by the end of study, indicating a small fraction of CD30 - cells might have escaped from bystander killing in these two remaining tumors.
p>
target
| Auristatin
|
D8-MMAE Preparation Products And Raw materials
Raw materials
Preparation Products
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D8-MMAE Suppliers
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- 0512-81877925 051281877925
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- China
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View Lastest Price from D8-MMAE manufacturers
Hangzhou Huarong Pharm Co., Ltd.
- Product
- D8-MMAE 2070009-72-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 1mg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-09-15