D8-MMAE

Product Name: D8-MMAE
CAS No.: 2070009-72-0
Chemical Name: D8-MMAE
Synonyms: MMAE-d8;D8-MMAE;2H8]-MMAE;MMAE-d-8,MMAE d8,MMAEd8;D8-Monomethyl auristatin E
CBNumber: CB12715624
Molecular Formula: C39H59D8N5O7
Formula Weight: 726.027874224
MOL File: 2070009-72-0.mol

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D8-MMAE Property

storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: DMSO : 100 mg/mL (137.74 mM; Need ultrasonic)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3368
Product name: D8-MMAE
Purity: 99.29%
Packaging: 1mg
Price: $1320
Updated: 2021/12/16

ChemScene

Product number: CS-3368
Product name: D8-MMAE
Purity: 99.29%
Packaging: 5mg
Price: $3000
Updated: 2021/12/16

ChemScene

Product number: CS-3368
Product name: D8-MMAE
Purity: 99.29%
Packaging: 10mg
Price: $5640
Updated: 2021/12/16

aablocks

Product number: AA01EOLQ
Product name: D8-MMAE
Purity: 99%
Packaging: 10mg
Price: $6302
Updated: 2021/12/16

aablocks

Product number: AA01EOLQ
Product name: D8-MMAE
Purity: 99%
Packaging: 5mg
Price: $3369
Updated: 2021/12/16

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D8-MMAE Chemical Properties,Usage,Production

Biological Activity

D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE. MMAE is a tubulin inhibitor that inhibits mitosis.

in vivo

Intratumoral MMAE concentrations consistently correlates with the extent of tumor growth inhibition in tumor xenograft models. IHC analysis reveals that nonbinding control-treated tumors consist of both CD30 ⁺ and CD30 ^- cells, presumably because they do not kill either CD30 ⁺ or CD30 ^- Karpas 299 cells. Only CD30 ^- cells are found in cAC10-vcMMAF-treated tumors, illustrating that cAC10-vcMMAF eliminates most CD30 ⁺ cells. Interestingly, the two tumors that relapses from cAC10-vcMMAE treatment are also found to be CD30 ^- by the end of study, indicating a small fraction of CD30 ^- cells might have escaped from bystander killing in these two remaining tumors.

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target

Auristatin

D8-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

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D8-MMAE Suppliers

China 27 India 1 United States 2 Global 30

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View Lastest Price from D8-MMAE manufacturers

Hangzhou Huarong Pharm Co., Ltd.

Product: D8-MMAE 2070009-72-0
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-15

2070009-72-0, D8-MMAERelated Search:

Propylthiouracil

D8-MMAE

D8-Monomethyl auristatin E

MMAE-d8

2H8]-MMAE

MMAE-d-8,MMAE d8,MMAEd8

2070009-72-0