ChemicalBook > CAS DataBase List > 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

Product Name
3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
CAS No.
886047-22-9
Chemical Name
3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
Synonyms
CS-2803;LY2119620;Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR,LY-2119620,LY 2119620,LY2119620;3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide;3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide;Thieno[2,3-b]pyridine-2-carboxamide,3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-;3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide USP/EP/BP
CBNumber
CB12716025
Molecular Formula
C19H24ClN5O3S
Formula Weight
437.94
MOL File
886047-22-9.mol
More
Less

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Property

Boiling point:
692.4±55.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
12.90±0.20(Predicted)
color 
White to light yellow
CAS DataBase Reference
886047-22-9
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26373
Product name
LY2119620
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
26373
Product name
LY2119620
Packaging
10mg
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
26373
Product name
LY2119620
Packaging
5mg
Price
$198
Updated
2024/03/01
Tocris
Product number
6964
Product name
LY2119620
Purity
≥98%(HPLC)
Packaging
10
Price
$152
Updated
2021/12/16
Tocris
Product number
6964
Product name
LY2119620
Purity
≥98%(HPLC)
Packaging
50
Price
$642
Updated
2021/12/16
More
Less

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Chemical Properties,Usage,Production

Description

LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 μM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh; ) and the mAChR agonists iperoxo and oxotremorine M at human recombinant M2 and M4 receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response).

Uses

LY 2119620 acts as a novel positive allosteric modulator in the treatment of schizophrenia acting as an anti-psychotic agent.

storage

Store at -20°C

References

[1]. croy ch, schober da, xiao h, et al. characterization of the novel positive allosteric modulator, ly2119620, at the muscarinic m(2) and m(4) receptors. mol pharmacol, 2014, 86(1): 106-115. kruse ac, ring am, manglik a, et al. activation and allosteric modulation of a muscarinic acetylcholine receptor. nature, 2013, 504(7478): 101-106.schober da, croy ch, xiao h, et al. development of a radioligand, [(3)h]ly2119620, to probe the human m(2) and m(4) muscarinic receptor allosteric binding sites. mol pharmacol, 2014, 86(1): 116-123.

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Suppliers

China 61 India 1 United States 9 Global 71
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6773
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4565
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8010
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Anyinuo Biomedical Technology Co., Ltd.
Tel
021-34625901
Email
420970979@qq.com
Country
China
ProdList
5783
Advantage
58

886047-22-9, 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMideRelated Search:

Bortezomib 42-(Dimethylphosphinate)rapamycin 17-DMAG Temozolomide GDC-0879 Rapamycin

  • 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
  • 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
  • LY2119620
  • CS-2803
  • Thieno[2,3-b]pyridine-2-carboxamide,3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-
  • 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide USP/EP/BP
  • Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR,LY-2119620,LY 2119620,LY2119620
  • 886047-22-9
  • Inhibitors