ChemicalBook > CAS DataBase List > (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

Product Name
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
CAS No.
475473-26-8
Chemical Name
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
Synonyms
CORM-3;CORM-3, 10 mM in DMSO;Carbon monoxide releasing molecule 3;Tricarbonylchloro(glycinato)ruthenium;Tricarbonylchloro(glycinato)ruthenium (II);(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium;(OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium;Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-;inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR)
CBNumber
CB12717709
Molecular Formula
C5H3ClNO5Ru
Formula Weight
293.6
MOL File
475473-26-8.mol
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(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Property

storage temp. 
-20°C
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
light yellow to dark yellow
Water Solubility 
Soluble to 100 mM in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0496
Product name
CORM-3
Packaging
10mg
Price
$126
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0496
Product name
CORM-3
Packaging
50mg
Price
$510
Updated
2025/07/31
Tocris
Product number
5320
Product name
CORM3
Packaging
50
Price
$357
Updated
2021/12/16
Usbiological
Product number
255030
Product name
CORM 3
Packaging
10mg
Price
$333
Updated
2021/12/16
TRC
Product number
C724813
Product name
CORM3
Packaging
25mg
Price
$695
Updated
2021/12/16
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(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties,Usage,Production

Uses

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H2O2-induced apoptosis using primary rabbit lens epithelial cells.

Biochem/physiol Actions

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

in vivo

CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice[2].

Animal Model:WT mice (C57BL/6J male, 8e10 weeks old)[2].
Dosage:4 mg/kg.
Administration:IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130.
Result:Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge in vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged.
Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged.

IC 50

NLRP3

storage

Store at -20°C

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Preparation Products And Raw materials

Raw materials

Preparation Products

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(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Suppliers

China 71 India 1 United Kingdom 1 United States 11 Global 84
Energy Chemical
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+1 (866) 333-9607
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939
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021-50706099
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shenlinxing@macklin.cn
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China
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AdooQ Bioscience CHINA
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Sigma-Aldrich
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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Target molecule Corp.
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857-239-0968
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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China
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View Lastest Price from (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
CORM-3 475473-26-8
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-08

475473-26-8, (OC-6-44)-Tricarbonylchloro(glycinato)rutheniumRelated Search:


  • (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
  • CORM-3
  • Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-
  • Carbon monoxide releasing molecule 3
  • Tricarbonylchloro(glycinato)ruthenium (II)
  • Tricarbonylchloro(glycinato)ruthenium
  • inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR)
  • (OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium
  • CORM-3, 10 mM in DMSO
  • 475473-26-8
  • C5H4ClNO5Ru
  • Inhibitors