(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
- Product Name
- (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
- CAS No.
- 475473-26-8
- Chemical Name
- (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
- Synonyms
- CORM-3;CORM-3, 10 mM in DMSO;Carbon monoxide releasing molecule 3;Tricarbonylchloro(glycinato)ruthenium;Tricarbonylchloro(glycinato)ruthenium (II);(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium;(OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium;Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-;inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR)
- CBNumber
- CB12717709
- Molecular Formula
- C5H3ClNO5Ru
- Formula Weight
- 293.6
- MOL File
- 475473-26-8.mol
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Property
- storage temp.
- -20°C
- solubility
- H2O: soluble20mg/mL, clear
- form
- powder
- color
- light yellow to dark yellow
- Water Solubility
- Soluble to 100 mM in water
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0496
- Product name
- CORM-3
- Packaging
- 10mg
- Price
- $126
- Updated
- 2025/07/31
- Product number
- SML0496
- Product name
- CORM-3
- Packaging
- 50mg
- Price
- $510
- Updated
- 2025/07/31
- Product number
- 5320
- Product name
- CORM3
- Packaging
- 50
- Price
- $357
- Updated
- 2021/12/16
- Product number
- 255030
- Product name
- CORM 3
- Packaging
- 10mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- C724813
- Product name
- CORM3
- Packaging
- 25mg
- Price
- $695
- Updated
- 2021/12/16
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties,Usage,Production
Uses
CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H2O2-induced apoptosis using primary rabbit lens epithelial cells.
Biochem/physiol Actions
CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.
in vivo
CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice[2].
| Animal Model: | WT mice (C57BL/6J male, 8e10 weeks old)[2]. |
| Dosage: | 4 mg/kg. |
| Administration: | IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130. |
| Result: | Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge in vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged. Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged. |
IC 50
NLRP3
storage
Store at -20°C
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Preparation Products And Raw materials
Raw materials
Preparation Products
(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium manufacturers
- Product
- CORM-3 475473-26-8
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-08