4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

Product Name: 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
CAS No.: 211230-35-2
Chemical Name: 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
Synonyms: AvafilImpurity30;4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine;4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester;4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester;4-(4-Methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester;Ethyl 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate (Avanafil Impurity);5-Pyrimidinecarboxylic acid, 4-[[(4-methoxyphenyl)methyl]amino]-2-(methylthio)-, ethyl ester
CBNumber: CB12721078
Molecular Formula: C16H19N3O3S
Formula Weight: 333.41
MOL File: 211230-35-2.mol

More

Less

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Property

Boiling point:: 493.6±35.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 2.81±0.10(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 100mg
Price: $207
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 250mg
Price: $242
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 1g
Price: $409
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 5g
Price: $1002
Updated: 2021/12/16

Ambeed

Product number: A659647
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $24
Updated: 2021/12/16

More

Less

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Chemical Properties,Usage,Production

Uses

4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester is used in the preparation of pyrimidine derivatives for the treatment of metabolic bone disease.

Synthesis

5909-24-0

2393-23-9

211230-35-2

Example 14: Synthesis of ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate To a 60 mL solution of tetrahydrofuran containing ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (6.05 g, 26.07 mmol) was sequentially added triethylamine (11 mL, 79.5 mmol) and 4-methoxybenzylamine (3.6 mL, 27.6 mmol) at room temperature. The reaction mixture was stirred for 1 h. The reaction solution was filtered and the resulting white solid was washed with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure. The residue was partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate (7.60 g, 88% yield) with a melting point of 72-74 °C. Elemental analysis: C16H19N3O3S Calculated values: c, 57.64; h, 5.74; n, 12.60. Measured values: C, 57.65; H, 5.80; N, 12.57.

References

[1] Patent: US2004/224958, 2004, A1
[2] Patent: US6498163, 2002, B1
[3] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 94; 95

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Suppliers

China 45 India 1 United States 4 Global 50

Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Jinan Bond Chemical Technology Co., Ltd.

Tel: 86-531-88280989
Fax: 86-531-88280989
Email: mymail1996@126.com
Country: China
ProdList: 256
Advantage: 55

Suzhou Carbonwell Pharma-Tech Co., Ltd

Tel: 0512-0512-88981216 13776013740
Email: 1320558046@qq.com
Country: China
ProdList: 72
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2974
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9629
Advantage: 60

Aikon International Limited

Tel: 025-66061636 19370895928
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15812
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30227
Advantage: 58

211230-35-2, 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidineRelated Search:

Avanafil Impurity 24 Avanafil Impurity 19 Avanafil Impurity 9 Avanafil Impurity 26 Avanafil Impurity 16 Avanafil Impurity 10 Avanafil Impurity 25 Avanafil Impurity 20 Avanafil iMpurity 2 Avanafil Impurity 23 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid Avanafil iMpurity 5 5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- 1364671-52-2 Avanafil-13CD3 Avanafil Impurity 11 Avanafil iMpurity 3 Avanafil Impurity 21

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester

5-Pyrimidinecarboxylic acid, 4-[[(4-methoxyphenyl)methyl]amino]-2-(methylthio)-, ethyl ester

4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester

AvafilImpurity30

4-(4-Methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

Ethyl 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate (Avanafil Impurity)

211230-35-2