ChemicalBook > CAS DataBase List > 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

Product Name
4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
CAS No.
211230-35-2
Chemical Name
4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
Synonyms
AvafilImpurity30;4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine;4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester;4-(4-Methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester;4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-[[(4-methoxyphenyl)methyl]amino]-2-(methylthio)-, ethyl ester
CBNumber
CB12721078
Molecular Formula
C16H19N3O3S
Formula Weight
333.41
MOL File
211230-35-2.mol
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4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Property

Boiling point:
493.6±35.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
2.81±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
8992CD
Product name
Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging
100mg
Price
$207
Updated
2021/12/16
AK Scientific
Product number
8992CD
Product name
Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging
250mg
Price
$242
Updated
2021/12/16
AK Scientific
Product number
8992CD
Product name
Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging
1g
Price
$409
Updated
2021/12/16
AK Scientific
Product number
8992CD
Product name
Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging
5g
Price
$1002
Updated
2021/12/16
Ambeed
Product number
A659647
Product name
Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Purity
95+%
Packaging
100mg
Price
$24
Updated
2021/12/16
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4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Chemical Properties,Usage,Production

Uses

4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester is used in the preparation of pyrimidine derivatives for the treatment of metabolic bone disease.

Synthesis

5909-24-0

2393-23-9

211230-35-2

Example 14: Synthesis of ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate To a 60 mL solution of tetrahydrofuran containing ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (6.05 g, 26.07 mmol) was sequentially added triethylamine (11 mL, 79.5 mmol) and 4-methoxybenzylamine (3.6 mL, 27.6 mmol) at room temperature. The reaction mixture was stirred for 1 h. The reaction solution was filtered and the resulting white solid was washed with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure. The residue was partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate (7.60 g, 88% yield) with a melting point of 72-74 °C. Elemental analysis: C16H19N3O3S Calculated values: c, 57.64; h, 5.74; n, 12.60. Measured values: C, 57.65; H, 5.80; N, 12.57.

References

[1] Patent: US2004/224958, 2004, A1
[2] Patent: US6498163, 2002, B1
[3] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 94; 95

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Suppliers

China 44 India 1 United States 4 Global 49
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69

211230-35-2, 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidineRelated Search:

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  • 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
  • 4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester
  • 5-Pyrimidinecarboxylic acid, 4-[[(4-methoxyphenyl)methyl]amino]-2-(methylthio)-, ethyl ester
  • 4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester
  • AvafilImpurity30
  • 4-(4-Methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester
  • 211230-35-2