GLPG-0778
- Product Name
- GLPG-0778
- CAS No.
- 1206163-45-2
- Chemical Name
- GLPG-0778
- Synonyms
- CS-2178;G 154578;GLPG-0778;Solcitinib;GSK 2586184;GSK 2586184A;GLPG 0778;GLPG-0778;GLPG0778, GSK2586184;Solcitinib（GLPG0778）;Solcitinib (GSK2586184)
- CBNumber
- CB12725627
- Molecular Formula
- C22H23N5O2
- Formula Weight
- 389.45
- MOL File
- 1206163-45-2.mol
GLPG-0778 Property
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 2 mg/ml; DMSO: 5 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 7.99±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23439
- Product name
- Solcitinib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 23439
- Product name
- Solcitinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 23439
- Product name
- Solcitinib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 23439
- Product name
- Solcitinib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- CS-5204
- Product name
- Solcitinib
- Purity
- 99.59%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
GLPG-0778 Chemical Properties,Usage,Production
Description
Solcitinib is a JAK1 inhibitor (IC50 = 9.8 nM). It is greater than 10-fold selective for JAK1 over JAK2, JAK3, and TYK2.
Uses
Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis.
IC 50
JAK1: 9.8 nM (IC50)
References
[1] Ludbrook VJ, et al. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br J Dermatol. 2016 May;174(5):985-95. DOI:10.1111/bjd.14399
GLPG-0778 Preparation Products And Raw materials
Raw materials
Preparation Products
GLPG-0778 Suppliers
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