1-(3-Fluoro-pyridin-4-yl)-ethanol
- Product Name
- 1-(3-Fluoro-pyridin-4-yl)-ethanol
- CAS No.
- 87674-15-5
- Chemical Name
- 1-(3-Fluoro-pyridin-4-yl)-ethanol
- Synonyms
- 1-(3-Fluoro-pyridin-4-yl)-ethanol;4-(1-hydroxyethyl)-3-fluoropyridine;3-fluoro-a-methyl-4-Pyridinemethanol;4-Pyridinemethanol, 3-fluoro-a-methyl-;4-Pyridinemethanol, 3-fluoro-α-methyl-;3-FLUORO-ALPHA-METHYL-4-PYRIDINEMETHANOL
- CBNumber
- CB12727601
- Molecular Formula
- C7H8FNO
- Formula Weight
- 141.14
- MOL File
- 87674-15-5.mol
1-(3-Fluoro-pyridin-4-yl)-ethanol Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600180
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanol
- Packaging
- 25mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- F600180
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanol
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4128CU
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanol
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- A312744
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- CM255505
- Product name
- 1-(3-Fluoropyridin-4-yl)ethanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
1-(3-Fluoro-pyridin-4-yl)-ethanol Chemical Properties,Usage,Production
Synthesis
372-47-4
75-07-0
87674-15-5
To a stirred solution of 3-fluoropyridine (14 g, 144.2 mmol) in anhydrous THF (150 mL), cooled to -78°C under argon protection, a n-heptane/THF/ethylbenzene solution (79.2 mL, 158.6 mmol) of lithium 2 N diisopropylammonium (LDA) was added slowly dropwise over a period of about 1 hour. After stirring for 2.5 hours, a solution of acetaldehyde (8.9 mL, 158.5 mmol) in 25 mL of anhydrous THF cooled to about 0°C was added slowly dropwise and the reaction mixture was continued to be stirred at -78°C for 1.5 hours. Subsequently, the reaction solution was slowly warmed to -30 °C and the reaction was quenched by the addition of a solution of ammonium chloride (150 g) in 700 mL of water. The mixture was extracted with ethyl acetate (3 x 400 mL) and the combined organic layers were washed with brine (4 x 200 mL) and dried over anhydrous sodium sulfate. After concentrating the organic phase, the residual oily material was crystallized with hexane (40 mL) to give 15.6 g (76% yield) of 1-(3-fluoropyridin-4-yl)ethanol.
References
[1] Patent: WO2005/13986, 2005, A1. Location in patent: Page/Page column 44
[2] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2007/96334, 2007, A1. Location in patent: Page/Page column 31-32
[4] Tetrahedron, 1983, vol. 39, # 12, p. 2009 - 2021
1-(3-Fluoro-pyridin-4-yl)-ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
1-(3-Fluoro-pyridin-4-yl)-ethanol Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 1-(3-Fluoro-pyridin-4-yl)-ethanol manufacturers
- Product
- 4-(1-hydroxyethyl)-3-fluoropyridine 87674-15-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-05